The main goal of this talk is to review a new method’ for predicting, from QCD, the weak matrix elements that are needed to describe the semileptonic decays; B -+ DePe,,B + D’ec, and Ab + A,eti,. The method also relates B + pe& semileptonic decay to D + pZuc semileptonic decay. Since these are exclusive decays involving hadronic states nonperturbative strong interaction physics plays a role. Th...