Deletions and other genome rearrangements are associated with carcinogenesis and inheritable diseases. The pink-eyed unstable (pun) mutation in the mouse is caused by duplication of a 70-kb internal fragment of the p gene. Spontaneous reversion events in homozygous pun/pun mice occur through deletion of a duplicated sequence. Reversion events in premelanocytes in the mouse embryo detected as bl...

Dynamic contrast-enhanced study in magnetic resonance imaging (DCE-MRI) is an important tool in oncology to visualize tissues vascularization and to define tumour aggressiveness on the basis of an altered perfusion and permeability. Pharmacokinetic models are generally used to extract hemodynamic parameters, providing a quantitative description of the contrast uptake and wash-out. Empirical fun...

The article by Goldberg and colleagues found in this issue is a meticulous history of the changes in incidence and in-hospital and long term case fatality rates of myocardial infarction (MI) for a defined New England community from 1975 to 1995 (1). The authors suggest that there is a decline in the incidence of acute MI as well as in the short term and one-year mortality in survivors postdisch...

In this paper we present an innovative work on a multiagent joking conversational system. In our research so far we have shown that implementing humor into a chatterbot can visibly improve its performance. The results presented in this paper are the outcome of the next step of our work. They show that a multiagent system, combining a conversational agent, a pun generator and an emotiveness anal...