نتایج جستجو برای: warfarin reversal
تعداد نتایج: 44044 فیلتر نتایج به سال:
Warfarin sodium is an effective oral anticoagulant drug. However, warfarin has a narrow therapeutic window with significant risks of hemorrhage at therapeutic concentrations. Dosing is difficult and requires frequent monitoring. New oral anticoagulant agents are required to improve current anticoagulant therapy. Furthermore, while warfarin is effective in venous disease, it does not provide mor...
The last 70 years of Warfarin use has been associated with extreme problems. The Novel Oral Anticoagulants (NOACs) are not well utilized in patients with Atrial Fibrillation (AF). We thought to excavate the clinical utility of NOACs and provide some insights into their usefulness as suitable alternatives to Warfarin. Methods: The main objective is to raise awareness of clinicians regarding the ...
We thank Hifumi et al for their comments on our article. 1 It is important to recognize that treatment of major bleeding on warfarin in the 5 phase III trials was according to local hospital guidelines and protocols, which are generally based on international recommendations. 2 The low reversal rate of warfarin is surprising but reflects the way warfarin-associated bleeding was managed at the e...
INTRODUCTION Prothrombin Complex Concentrate (PCC) for reversal of warfarin is the main therapeutic option in cases of life-threatening bleeding. Aim of the study was to investigate for using 4-factor PCC brought to the therapeutic levels of International Normalized Ratio (INR) values in cases of life-threatening bleeding in Emergency Department. METHODS This retrospective cohort study was pe...
BACKGROUND AND PURPOSE Based on an experimental model of warfarin-associated intracerebral hemorrhage, we investigated whether the rapid reversal of anticoagulation using prothrombin complex concentrates (PCC) or recombinant activated coagulation factor VII (rFVIIa) reduces hematoma volume. METHODS Mice were orally pretreated with warfarin (2 mg/kg). Intracerebral hemorrhage was induced by co...
background: warfarin is a common anticoagulant drug that has a narrow therapeutic index; higher dose causes excessive bleeding and lower dose leads to cerebrovascular clotting and stroke in patients. genetic factors that have been associated with warfarin response are the genes of cytochrome p450 2c9 (cyp2c9), which metabolize the more active s-enantiomer of warfarin, and vitamin k epoxide redu...
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