نتایج جستجو برای: warfarin
تعداد نتایج: 9538 فیلتر نتایج به سال:
Although drug interactions with warfarin are an important cause of excessive anticoagulation, their impact on the risk of serious bleeding is unknown. We therefore performed a cohort study and a nested case-control analysis to determine the risk of serious bleeding in 4152 patients (aged 40-84 years) with nonvalvular atrial fibrillation (AF) taking long-term warfarin (> 3 months). The study pop...
Long-term use of warfarin has been shown to be associated with a reduced risk of prostate cancer. Warfarin belongs to the vitamin K antagonist class of anticoagulants, which inhibit vitamin K epoxide reductase (VKOR). The vitamin K cycle is primarily known for its role in γ-carboxylation, a rare post-translational modification important in blood coagulation. Here we show that warfarin inhibits ...
The warfarin drug is an oral anticoagulant have prominent side effects on the body organs when it used for treatment of cardiovascular system diseases, current study focused to investigation histo logical and bio chemical change in kidney male white mice after being treated with 30 day. present work carryout 40 males mice, all laboratory animals were housed animal house sciences college / AL-Mu...
Warfarin has been associated with bleeding and venous thromboembolism. Objective: This study aimed to estimate the association between concomitant self-medication, incidence of adverse drug reactions in patients using warfarin. Setting: public health network Ijuí, a municipality southern Brazil. was an open prospective cohort, conducted for period 18 months users warfarin, treated at service. T...
Warfarin, a widely prescribed drug for preventing thrombosis, is thought to act solely through inhibition of vitamin K-dependent coagulation factors. Low concentrations of warfarin inhibit interleukin-6 production and phosphorylation of I-kappa B but not activation of p38 mitogen-activated protein kinase. Thus, warfarin inhibits inflammatory signal transduction, and this may contribute to clini...
Interactions of warfarin with other drugs or substances can pose a serious problem. We assessed three drug information compendia-Clinical Pharmacology, ePocrates, and Micromedex-and the warfarin sodium (Coumadin) product label (August 2007) approved by the US Food and Drug Administration for listings of interactions between warfarin and drugs, biologics, foods, and dietary supplements. The drug...
Warfarin is a vitamin K antagonist that genetic and non-genetic factors affected on its dose requirement in the patients with cardio vascular disease. The aim of this study was whether the APOE and VKORC1 polymorphisms influence on warfarin dose requirements in the part of Iranian patients. Blood samples were collected from 86 warfarin-treated patients. After extraction of genomic DNA, the VKOR...
Rifampicin induces multiple detoxification pathways, including those mediated by enzymes of the cytochrome P450 (CYP) family such as CYP2C9 and CYP3A4 [1], and is a known perpetrator of metabolic drug-drug interactions (mDDIs). Warfarin is a narrow therapeutic index anti-coagulant drug that is primarily cleared via CYP-mediated metabolism, and as such is a plausible victim of mDDIs with clinica...
BACKGROUND Although warfarin is widely recommended to prevent atrial fibrillation-related thromboembolism, many eligible patients do not take warfarin. The objective of this study was to describe factors associated with warfarin discontinuation in patients newly starting warfarin for atrial fibrillation. METHODS AND RESULTS We identified 4188 subjects newly starting warfarin in the Anticoagul...
BACKGROUND AND PURPOSE Intracranial hemorrhage rates are higher in Asians than non-Asians, especially in patients receiving warfarin. This randomized evaluation of long-term anticoagulation therapy subgroup analysis assessed dabigatran etexilate (DE) and warfarin effects on stroke and bleeding rates in patients from Asian and non-Asian countries. METHODS There were 2782 patients (15%) from 10...
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