Identifying the neuronal circuits and dynamics of sleep-to-wake transition is essential to understanding brain regulation of behavioral states, including sleep-wake cycles, arousal, and hyperarousal. Recent work by different laboratories has used optogenetics to determine the role of individual neuromodulators in state transitions. The optogenetically driven data do not yet provide a multi-dime...

We study the behavior of an elastic loop embedded in a flowing soap film. This deformable loop is wetted into the film and is held fixed at a single point against the oncoming flow. We interpret this system as a two-dimensional flexible body interacting in a two-dimensional flow. This coupled fluid-structure system shows bistability, with both stationary and oscillatory states. In its stationar...

A concept is presented for the development and implementation of a prototype Aircraft Vortex Spacing System (AVOSS). The purpose of the AVOSS is to use current and short-term predictions of the atmospheric state in approach and departure corridors to provide, to ATC facilities, dynamical weather dependent separation criteria with adequate stability and lead time for use in establishing arrival ...

Abstract Sleep states in infancy differ from adult sleep states. Due to different cortical and physical manifestations, the REM NREM equivalent infants are often denoted as Active Quiet sleep. Key differences infant REM-NREM cycling include rapid cycling, commencement of state, instead NREM. The physiological mechanisms underlying developmental changes not well understood. We extended an existi...

A square splittered and unsplittered rod is placed in a turbulent boundary layer developed over a flat plate. The effect of the resulting disturbances on the local heat transfer coefficient is then studied. In both cases the square rod modifies the flow structure inside the boundary layer. As a result, a stagnation point, a jet and wake area are generated around the square rod, each making a co...

A wake model for the free-streamline theory is proposed to treat the two-dimensional flow past an obstacle with a wake or cavity formation. In this model the wake flow is approximately described in the large by an equivalent potential flow such that along the wake boundary the pressure first assumes a prescribed constant under-pressure in a region downstream of the separation points (called the...

Despite significant progress in elucidating the molecular basis for circadian oscillations, the neural mechanisms by which the circadian clock organizes daily rhythms of behavioral state in mammals remain poorly understood. The objective of this review is to critically evaluate a conceptual model that views sleep expression as the outcome of opponent processes-a circadian clock-dependent alerti...