نتایج جستجو برای: von willebrand factor
تعداد نتایج: 931957 فیلتر نتایج به سال:
BACKGROUND Aortic-valve stenosis can be complicated by bleeding that is associated with acquired type 2A von Willebrand syndrome. However, the prevalence and cause of the hemostatic abnormality in aortic stenosis are unknown. METHODS We enrolled 50 consecutive patients with aortic stenosis, who completed a standardized screening questionnaire to detect a history of bleeding. Forty-two patient...
The life cycle of von Willebrand factor (VWF) comprises a number of distinct steps, ranging from the controlled expression of the VWF gene in endothelial cells and megakaryocytes to the removal of VWF from the circulation. The various aspects of VWF clearance have been the objects of intense research in the last few years, stimulated by observations that VWF clearance is a relatively common com...
Precipitating antibodies to factor VlIl/von Willebrand factor can develop in patients with severe homozygouslike von Willebrand’s disease following multiple transfusions with blood derivatives. This study of 4 patients treated with cryoprecipitate for 1 3 different bleeding episodes demonstrates that the occurrence of such antibodies interferes with the management of the disease. The control of...
Human Factor VIII/von Willebrand factor, purified by calcium citrate-cellulose chromatography and 4% agarose gel filtration was subjected to sodium dodecyl sulfate gel electrophoresis on gels containing 2% acrylamide and 0.5% agarose. We find a series of multimers of which the apparent molecular weight of the higher members was congruent with5 million. The higher multimers were isolated by 2% a...
Glycoprotein llb-IRa (ctnbB3) and the vitronectin receptor (ct~B3), two integrins that share the common #3 subunit, have been reported to function as promiscuous receptors for the RGD-containing adhesive proteins fibrinogen, vitronectin, fibronectin, yon Willebrand factor, and thrombospondin. The present study was designed to establish a cell system for the expression of either GP IIb-IIIa or t...
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