Kankkunen, T., 2002. Controlled transdermal drug delivery by iontophoresis and ionexchange fiber. Dissertationes Biocentri Viikki Universitatis Helsingiensis 17/2002, pp. 57 ISBN 952-10-0313-8 (print) ISBN 952-10-0314-6 (pdf) ISSN 1239-9469 A common aim in the development of new transdermal devices is the controlled delivery of drugs, so that the rate of drug input into the blood stream is pred...

Inhibition of the interaction between scaffolding protein PSD-95 and NMDA receptor has been shown to obstruct ischemic stroke-triggered excitotoxic reactions, leading neuronal death. The peptides NR2B9c N -dimer are inhibitors this interaction. Delivery brain is challenging due general low blood–brain barrier (BBB) permeability. have therefore conjugated cell-penetrating peptide (CPP) Tat, faci...

Objectives: The objective of existent effort was topical proniosomal gel formulation and evaluation from the proniosomes Ciclopirox to improve poor skin penetration residence antifungal drugs. Methods: co-acervation phase separation method used prepare by using combination different grades non-ionic surfactant, cholestrol lecithin. Characterized for pH, encapsulation efficiency, Particle size, ...

Candesartan cilexetil (CC) is an angiotensin II-receptor blocker (ARB). The antihypertensive effect of CC 4-16 mg/day was as great that other once-daily dosage regimens. has high first-pass metabolism and low oral bioavailability. bioavailability such drugs may be significantly improved if delivered through the buccal route; hence mucosal delivery one alternative methods systemic drug delivery....

Objective: The present research was aimed to develop ketoconazole (KT) loaded microemulsion-based gel formulation for effective topical delivery through enhanced drug solubility, improved skin permeation and reduced side effects overcoming drawbacks of conventional dosage forms. Methods: For the selection oil, surfactant co-surfactant mixture (Smix) ratio, phase titration method used pseudo-ter...

many properties of chemicals depend on their stereochemistry. among these, the effects of stereoisomerism on percutaneous absorption of drugs are not well studied. we have previously shown that permeation of tretinoin and isotretinoin (two geometric isomers) through hydrophilic enhancers-treated rat skin is stereoselective. as, depending on their lipophilicity, penetration enhancers can change ...

in this work we sought to determine whether vesicles (liposomes/niosomes) were able to enhance finasteride concentration in the dermis layer, including the pilosebaceous units (psu). such enhancement could be beneficial in the treatment of some androgen-related skin disorders. hamster flank skin was used to study  3hfinasteride permeation via vesicles and a hydroalcoholic solution (ha). the dru...

Although permeation of hydrocarbons such as Benzene, Toluene, Ethybenzene, and Xylene (BTEX) through polyethylene (PE) pipe in potable water applications is rarely occurred. It is important to understand permeation mechanism and characterize the potential health risk. The most common potential hydrocarbon substances are originated from gasoline leaks. Previous research has shown that pipe mater...