PURPOSE The authors applied a novel microindentation technique to characterize biomechanical properties of small ocular and orbital tissue specimens using the hertzian viscoelastic formulation, which defines material viscoelasticity in terms of the contact pressure required to maintain deformation by a harder body. METHODS They used a hard spherical indenter having 100 nm displacement and 100...

Forgacs et al. have developed a continuum model for cellular aggregates that has at its basis the work of Steinberg and co-workers concerning the coalescence of cells that takes into account surface tension effects, to describe the response of embryonic tissues. Here, we propose a solid model that reflects the fact that such embryonic tissues in the bulk (not at the cellular level) behave like ...

Hyaluronan is a major carbohydrate component of the extracellular matrix and can be found in skin, joints, eyes and most other organs and tissues. It has a simple, repeated disaccharide linear copolymer structure that is completely conserved throughout a large span of the evolutionary tree, indicating a fundamental biological importance. Amongst extracellular matrix molecules, it has unique hyg...

The work is devoted to the development of a mathematical model foam material filtering half mask. analysis methods used study leveling negative effect compression pressure half-mask on soft tissues human face under conditions long-term operation was carried out. In order mutual influence in medium "filter - tissues", it proposed conduct virtual tests using numerical methods. models linear visco...

Since the physical behavior of many tissues is shown to be viscoelastic, we propose a novel registration technique for medical images via physical principles of viscoelasticity. It allows the template and the target images to differ by large local deformations like viscous fluid and small local deformations like elastic solid. With an extra elastic term introduced, the proposed model constrains...

INTRODUCTION Arguably, the biological basis of the mechanical properties observed in epithelial tissues resides within the complex threedimensional arrangement of intercellular junctions that serve to anchor intracellular actin and intermediate filament networks of individual cells. Morphologically, anchoring junctions are often classified as (i) cell-cell junctions: adherens junctions and desm...

Biological materials, such as isolated protein networks, tissues and living cells are extremely heterogeneous and contain structures on length scales from nanometers to hundreds of microns. Their complex geometries and sensitivity to environmental conditions make traditional measurements of structure and mechanics difficult, challenging experimenters to develop new techniques. In this work, we ...

This study examined the time-dependent response of bovine periodontal ligament (PDL). Applying linear viscoelastic theory, the objective was 1) to examine the linearity of the PDL's response in terms of its scaling and superposition property and 2) to generate the phase lag-vs.-frequency spectrum graph. PDL specimens were tested under three separate straining conditions: 1) tension ramp tests c...

The mechanical behaviour of solid biological tissues has long been described using models based on classical continuum mechanics. However, the classical continuum theories of elasticity and viscoelasticity cannot easily capture the continual remodelling and associated structural changes in biological tissues. Furthermore, models drawn from plasticity theory are difficult to apply and interpret ...