Infections with nonsporing anaerobes are common and often pose diagnostic and therapeutic challenges. There is an increasing trend of resistance among anaerobes against the commonly used antibiotics. Lot of development has occurred in terms of molecular and biochemical basis for pathogenecity and virulence factors among nonsporing anaerobes. Therefore, there is a need for development of newer, ...

The nature of the virulence of micro-organisms has been investigated by many workers in an effort to determine the influences and mechanisms involved. Such investigations have, in the main, dealt with the study of various factors associated with virulence, but there is no evidence that such factors contribute to the make-up of virulence. The pigment of staphylococcus is an example of a factor i...

Citation: Demirel I, Persson A, Brauner A, Särndahl E, Kruse R and Persson K (2018) Activation of the NLRP3 Inflammasome Pathway by Uropathogenic Escherichia coli Is Virulence Factor-Dependent and Influences Colonization of Bladder Epithelial Cells. Front. Cell. Infect. Microbiol. 8:81. doi: 10.3389/fcimb.2018.00081 Activation of the NLRP3 Inflammasome Pathway by Uropathogenic Escherichia coli ...

Listeriolysin O (LLO) is an essential virulence factor for the gram-positive bacterium Listeria monocytogenes. Our goal was to determine if altering the topology of LLO would alter the virulence and toxicity of L. monocytogenes in vivo. A recombinant strain was generated that expressed a surface-associated LLO (sLLO) variant secreted at 40-fold-lower levels than the wild type. In culture, the s...