نتایج جستجو برای: vinca herbacea extract

تعداد نتایج: 177882  

Journal: :Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999
C Dumontet B I Sikic

PURPOSE To analyze the available data concerning mechanisms of action of and mechanisms of resistance to the antitubulin agents, vinca alkaloids and taxanes, and more recently described compounds. DESIGN We conducted a review of the literature on classic and recent antitubulin agents, focusing particularly on the relationships between antitubulin agents and their intracellular target, the sol...

2006
Ahmad R. Safa Constance J. Glover Ronald L. Felsted

The cytotoxic, antimitotic, and growth inhibition properties of a pho toactive analogue of vinblastine, Ar-(p-azidobenzoyl)-A''-0-aminoethylvindesine (NÕBV), and vinblastine on P388 murine leukemia cells were compared. After 72-h exposure, the 50% drug-inhibitory concentrations for exponentially growing P388 leukemic cells were 1.2 n\i for NABV and 0.6 n\i for vinblastine. The ultrastructural ...

ژورنال: :تحقیقات مرتع و بیابان ایران 2012
بهرام امیری محمدحسن عصاره محمد جعفری بهروز رسولی علی اشرف جعفری

امروزه در دنیا پذیرفته شده است که برای مقابله با کمبود غذا برای انسان و دام چاره­ای جز استفاده از گیاهان مقاوم به شوری و خشکی وجود ندارد. دانشمندان و اکولوژیستها پیوسته در حال تحقیق بر روی گونه­هایی هستند که ضمن تحمل این تنش­ها بتوانند بخشی از نیاز جوامع بشری را رفع نمایند و یا از مکانیزم این گیاهان مقاوم بر روی محصولات راهبردی استفاده کنند. بنابراین شناخت این گونه­های مقاوم امری ضروری و اجتناب...

2017
Richard C Wang Xinmei Chen Amadeo M Parissenti Anil A Joy Jack Tuszynski David N Brindley Zhixiang Wang

INTRODUCTION One of the main reasons for disease recurrence in the curative breast cancer treatment setting is the development of drug resistance. Microtubule targeted agents (MTAs) are among the most commonly used drugs for the treatment of breaset cancer and therefore overcoming taxane resistance is of primary clinical importance. Our group has previously demonstrated that the microtubule dyn...

Journal: :Therapeutics and Clinical Risk Management 2008
Mark Bachner Maria De Santis

Vinflunine (VFL) is a third-generation bifluorinated semi-synthetic vinca alkaloid obtained by superacidic chemistry from its parent compound, vinorelbine. As with the other vinca alkaloids, the main antineoplastic effects of VFL arise from its interaction with tubulin, the major component of microtubules in mitotic spindles. In contrast to other vinca alkaloids, VFL shows some distinctive prop...

آیت الهی, عبدالمجید, آسمار, مهدی , عقیقی, زهره , فرهمند, مهین , قائمی, ناصر ,

Leishmaniasis affects 1.5-2 million people annually and has been recognized as a major public health problem by the World Organization.In Iran the incidence rate of the disease among school children in Ardestan province was 3.2 per thousand. As no effective vaccine has been found yet, control of the disease depends on effective drug therapy. The pentavalent anitmonials (pentostam and glucantime...

Journal: :Terra Roxa e Outras Terras: Revista de Estudos Literários 2023

Os artigos reunidos neste volume oferecem ao leitor uma perspectivação das formas como o horizonte tecnocultural contemporâneo vinca profundamente as práticas de criação literária. Nesse sentido, um problema recorrente consiste na busca modos apreensão conceitual fenômenos que esgarçam linhas imaginárias até então circunscreviam literárias.

2018
Xueping Lei Minfeng Chen Maohua Huang Xiaobo Li Changzheng Shi Dong Zhang Liangping Luo Youwei Zhang Nan Ma Heru Chen Huafeng Liang Wencai Ye Dongmei Zhang

Vinca alkaloids, the well-known tubulin-binding agents, are widely used for the clinical treatment of malignant tumors. However, little attention has been paid to their vascular disrupting effects, and the underlying mechanisms remain largely unknown. This study aims to investigate the vascular disrupting effect and the underlying mechanisms of vinca alkaloids. Methods: The capillary disruption...

Journal: :Cancer research 1991
B H Petersen S V DeHerdt D W Schneck T F Bumol

Monoclonal antibody (MoAb) conjugates have been used to treat a variety of malignancies. The majority of the MoAbs which have been used therapeutically are from murine sources. The infusion of these foreign proteins into humans can be expected to elicit anti-murine antibodies and may be one of the major limitations to the clinical use of murine MoAbs. In these studies, we report on the nature a...

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