We have used the interaction trap, a yeast two-hybrid system, to identify proteins interacting with hairy, a basic-helix-loop-helix (bHLH) protein that represses transcription during Drosophila embryonic segmentation. We find that the groucho (gro) protein binds specifically to hairy and also to hairy-related bHLH proteins encoded by deadpan and the Enhancer of split complex. The C-terminal WRP...

We present broad-band (2 keV to 2 MeV) x-ray spectra of GRO J1655{40, a luminous X-ray transient and occasional source of relativistic radio jets, obtained with the Rossi X-Ray Timing Explorer (RXTE) and the Oriented Scintillation Spectrometer Experiment (OSSE). In one observation, the luminosity is found to be 18% of the Eddington limit, which is one of the highest luminosities ever observed f...

We present broad-band (2 keV to 2 MeV) x-ray spectra of GRO J1655–40, a luminous X-ray transient and occasional source of relativistic radio jets, obtained with the Rossi X-Ray Timing Explorer (RXTE) and the Oriented Scintillation Spectrometer Experiment (OSSE). In one observation, the luminosity is found to be 18% of the Eddington limit, which is one of the highest luminosities ever observed f...

Previously we claimed that Black Hole X-ray Novae (BHXN) in quiescence are much less luminous than equivalent Neutron Star X-ray Novae (NSXN). This claim was based on the quiescent detection of a single short period BHXN (A0620–00, Porb=7.8 hrs) and two longer period BHXN (GRO J1655–40, Porb=62.9 hrs; V404 Cyg, Porb=155.3 hrs), along with sensitive upper limits. We announce the detection of two...

In eukaryotes, the ability of DNA-binding proteins to act as transcriptional repressors often requires that they recruit accessory proteins, known as corepressors, which provide the activity responsible for silencing transcription. Several of these factors have been identified, including the Groucho (Gro) and Atrophin (Atro) proteins in Drosophila. Here we demonstrate strong genetic interaction...

A full length cDNA clone of the platelet-derived growth factor-inducible KC gene has been isolated, sequenced, and expressed in COS cells. Both sequence analysis and expression studies indicate that KC encodes a secretory protein. Sequence analysis shows that, furthermore, the protein encoded by KC belongs to a growing superfamily of inducible proteins with a common ancestral linkage to the pla...

Ambient particulate matter (PM) is known to induce inflammation in the respiratory tract of exposed subjects. The aim of the present study was to detect, in bronchial epithelial cells, candidate inflammatory genes exhibiting transcriptional modifications following urban PM2.5 exposure. Paris urban PM2.5 sampled either at a curbside or a background station in winter and in summer was tested in c...

The repetitive X-ray bursts from the accretion-powered pulsar GRO J1744228 show similarities to the type II X-ray bursts from the Rapid Burster. Several authors (notably, Lewin et al.) have suggested that the bursts from GRO J1744228 are type II bursts (which arise from the sudden release of gravitational potential energy). In this paper, we present another similarity between these sources. Ros...

Global run-on sequencing (GRO-seq) is a recent addition to the series of high-throughput sequencing methods that enables new insights into transcriptional dynamics within a cell. However, GRO-sequencing presents new algorithmic challenges, as existing analysis platforms for ChIP-seq and RNA-seq do not address the unique problem of identifying transcriptional units de novo from short reads locat...