Background Hemophilia A and B are disorders resulting from a deficiency in factor VIII (FVIII), and factor IX (FIX), respectively. Tissue Factor (TF) is a key component of the extrinsic pathway and plays a role in the coagulation defect of hemophilic blood. Neutralizing the activity of TFPI represents a promising treatment concept in patients with hereditary or acquired hemophilia. ARC19499 is ...

Skin necrosis caused by heparins is a rare complication. We report a case of a 71-year-old woman who developed the unusual complication of focal necrotizing skin lesions in the injection site after undergoing thromboprophylaxis with enoxaparin after right knee arthroplasty. Laboratory investigations for heparine-induced thrombocytopenia (HIT), disseminated intravascular coagulation, protein C, ...

cerebral vein thrombosis (cvt) is an infrequent condition with a large variety of causes that can lead to serious disabilities. however, in 20% to 35% of cases, no cause is found. in this study we evaluated the hereditary (p & c proteins, antithrombin, mutation of prothrombin g20210a and factor v leiden), other risk factors (hyperhomocycteinemia, factor viii, acl-ab, apl-ab, and ocp) and clinic...

Hemarthrosis, the hallmark of severe hemophilia, is the major cause of serious bleeding events, disability and reduced quality of life in patients with factor VIII or factor IX deficiency. Joint bleeding is one of the greatest challenges confronting individuals treating hemophilia, and its economic impact is enormous. This article reviews the current management of hemophilic joint bleeding and ...

Hemophilia A is an X-linked recessive hereditary bleeding illness that manifests as increased after moderate trauma and spontaneous bleeding. It caused by a deficiency of the clotting factor VIII (FVIII). We report video assisted-thoracoscopy in 48-year-old patient with A. shouldn't be barrier to invasive surgery, but there are few conditions must met ensure straightforward intraoperative posto...

Automated procedures involving a chromogenic substrate sensitive to thrombin-sarcosine-Pro-Arg p-nitroanilide were compared with conventional tests for prothrombin times and activated partial thromboplastin times (APTT) and with specific assays for factors V, VII, VIII, IX, X, XI, and XII. The reproducibility and sensitivity of the chromogenic tests were compared with those of the clotting test...

Methylation, CpG island, promoter, intron 1 Haemophilia A is the most common X-linked inherited coagulation disorder caused by a deficiency of the factor VIII protein (FVIII). A plethora of different mutations in the factor VIII gene (F8) have been identified as causative for this bleeding disease including a few promoter mutations. However, in approximately 2-5% of all haemophilic patients, th...

Hemophilic pseudotumor is a rare complication of hemophilia, occurring in 1 to 2 percent of individuals with severe factor VIII or factor IX deficiency. A 35-year-old male presented with a swelling in the right lower abdomen for 3 months. There was no history of trauma. Examination revealed a swelling over the right iliac fossa. Right hip showed 30° flexion deformity. Blood investigations like ...

Acquired haemophilia is a rare autoimmune condition with an annual incidence of one per million. It is more common in the elderly and is associated with the presence of anti-factor VIII IgG antibodies. Most cases are idiopathic but there are also known associations with malignancy, other autoimmune diseases and drug interactions. As aging itself is not a cause of changes in range of coagulation...