The allele Mx regulates the extent to which interferon alpha/beta inhibits the growth of influenza viruses in mouse cells such as peritoneal macrophages. The time course of induction of the antiviral state against an influenza A virus is comparable in macrophages with and without Mx and is similar to that found with vesicular stomatitis virus. In contrast, the decay of the antiviral state again...

Neurotransmitter transporters play essential roles in the process of neurotransmission. Vesicular neurotransmitter transporters mediate storage inside secretory vesicles in a process that involves the exchange of lumenal H(+) for cytoplasmic transmitter. Retrieval of the neurotransmitter from the synaptic cleft catalyzed by sodium-coupled transporters is critical for the termination of the syna...

Though the general appearance and the cellular composition of the pancreatic islets of the Mongolian gerbil (Meriones unguiculatus) conformed to those of most other rodent species, some peculiar ultrastructural details were found. Thus there were diversiform, mainly vesicular particles with varying electron opacity in these islets. The vesicular particles showed a clear association to cilia whi...

Un cuadro de meningitis aséptica, en el contexto un paciente inmunosuprimido con diagnóstico infección por Virus Inmunodeficiencia Humana (VIH), debe llevar a pensar múltiples diagnósticos diferenciales. Entre estos, se incluye virus varicela zóster (VVZ) como uno los principales agentes causales líquido cefalorraquídeo claro. Su reactivación da lugar manifestaciones neurológicas potencialmente...

Numerous features distinguish prokaryotes from eukaryotes, chief among which are the distinctive internal membrane systems of eukaryotic cells. These membrane systems form elaborate compartments and vesicular trafficking pathways, and sequester the chromatin within the nuclear envelope. The nuclear pore complex is the portal that specifically mediates macromolecular trafficking across the nucle...

Vesicular lipoproteins (e.g., lipoprotein-X) are found in plasma in cholestasis or following infusion of Intralipid or phospholipid. To investigate the metabolism of vesicular lipoproteins, we isolated them from the plasma of subjects with cholestasis or following chronic or single Intralipid infusion. Cholestasis and chronic Intralipid therapy were found to be associated with elevated plasma c...

Vesicular neurotransmitter transporters package transmitter into the lumen of synaptic vesicles for quantal release. However, the number of transporters that localize to each vesicle is not known. In this issue of Neuron, a study by Daniels et al. using the Drosophila neuromuscular junction and mutations of the vesicular glutamate transporter suggests that one transporter may suffice to fill ea...

Simultaneous measurements of IVIEC and SCA by two nanotip electrodes allows direct dynamic comparison between vesicular transmitter content release to shed light on stimulation-induced plasticity.