BACKGROUND Up-regulation of tryptophan (Trp) conversion into kynurenine (Kyn) and increased formation of down-stream metabolites of Kyn is one of the mechanisms of aging and neurodegenerative disorders. Kyn is an immediate precursor of kynurenic acid (KYNA), an antagonist to NMDA and α7nAChR receptors and activator of aryl hydrocarbon receptor. Increased formation of KYNA ameliorates neurodegen...

We have surveyed three natural populations of Drosophila ananassae for restriction map variation at the forked c f ) and vermilion (v ) loci, using 6-cutter restriction enzymes. Both loci are located in the centromeric region of the X chromosome. Two major conclusions can be drawn from the data. First, we found strong evidence for population subdivision, i .e . , significant differences in the ...

The vermilion rockfish complex consists of two distinct species, (Sebastes miniatus) and sunset (S. crocotulus) with clear haplotypic differences. Due to a one-way mitochondrial introgression from into high proportion (20–30%) fish haplotype are characterized as based on nuclear genotype (introgressed sunset, hereafter, introgressed). Here we examined differences in the distribution biological ...

UPPRESSION is the complete or partial restoration of the wild-type phenotype by one gene in the presence of another nonallelic mutant gene that alone causes a mutant phenotype. Intragenic “suppressors” have also been reported (CRICK, BARNETT, BRENNER and WATTS-TOBIN 1961; HELINSKI and YANOFSKY 1963) but the term “second site reversion” used by HELINSKI and YANOFSKY seems useful in distinguishin...

background: hyperlipidemia is a well-documented risk factor for coronary heart disease and a great wealth of clinical trials have shown that early detection of hyperlipidemia and prescribing drugs that lower elevated lipid levels reduce serious cardiovascular events, such as myocardial infarction, heart failure and stroke. fordyce granules (fgs) are sebaceous glands without hair follicles, most...

Mosquera, D., B. Fessl, D. Anchundia, E. Heyer, C. Leuba, Nemeth, M. L. Rojas, Sevilla, and S. Tebbich. 2022. The invasive parasitic fly Philornis downsi is threatening Little Vermilion Flycatchers on the Galápagos Islands. Avian Conservation Ecology 17(1):6. https://doi.org/10.5751/ACE-02040-170106

Abstract Properly situating Giorgio de Chirico’s metaphysical works within his lifetime is complicated due to incomplete provenances, practice of deliberately falsifying dates, and the known existence forgeries. De palette may have altered over time, shifts in personal taste, changes availability materials, innovations paints; elucidating variations thereof during period (1911–1919) offers anal...