We tested the efficacy of preischemic and postischemic systemic treatment with 30,000 units polyethylene glycol-conjugated superoxide dismutase in a reperfusion model of focal cerebral ischemia. Forty-one anesthetized cats underwent 2 hours' occlusion of the left middle cerebral artery and both common carotid arteries followed by 4 hours of reperfusion. Cats were blindly assigned to one of thre...

The effects of recombinant human erythropoietin (rHuEPO) in diabetes-related healing defects were investigated by using an incisional skin-wound model produced on the back of female diabetic C57BL/KsJ-m(+/+)Lept(db) mice (db(+)/db(+)) and their normoglycemic littermates (db(+/+)m). Animals were treated with rHuEPO (400 units/kg in 100 microl s.c.) or its vehicle alone (100 microl). Mice were ki...

Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder associated with obesity and insulin resistance that often precedes the development of type-2 diabetes. Rats continuously exposed to dihydrotestosterone from prepuberty display typical reproductive and metabolic PCOS characteristics including anovulation, polycystic ovaries, insulin resistance, and obesity. Our aim was to ...

2 Acclimatization to hypoxia requires time to complete the adaptation mechanisms that influence 3 oxygen (O2) transport and O2 utilization. Although decreasing hemoglobin (Hb) O2 affinity 4 would favor the release of O2 to the tissues, increasing Hb-O2 affinity would augment arterial O2 5 saturation during hypoxia. This study was designed to test the hypothesis that 6 pharmacologically increasi...

Creating an autonomous flying vehicle the size of a honeybee presents a number of technical challenges because of its small scale. As vehicle wingspan diminishes, angular acceleration rates increase, necessitating sensing and control systems with high bandwidth. Hovering demonstrations have so far required feedback from highspeed motion capture cameras to estimate the angular velocity, attitude...

The proarrhythmic potential of digoxin, administered in a therapeutic dosage regimen, was evaluated in conscious dogs in the subacute phase of myocardial infarction. In this evaluation, digoxin (0.0125 mg/kg/day intravenously) or vehicle were administered to conscious dogs for periods of 5 to 7 days, commencing 4 to 5 days after anterior myocardial infarction. Before treatment, programmed ventr...

OBJECTIVE To determine whether state booster seat laws were associated with decreased fatality rates in children 4 to 7 years of age in the United States. METHODS Retrospective, longitudinal analysis of all motor vehicle occupant crashes involving children 4 to 7 years of age identified in the Fatality Analysis Reporting System from January 1999 through December 2009. The main outcome measure...

This paper describes a data set collected by MIT’s autonomous vehicle Talos during the 2007 DARPA Urban Challenge. Data from a high precision navigation system, 5 cameras, 12 SICK planar laser range scanners, and a Velodyne high density laser range scanner were synchronized and logged to disk for 90km of travel. In addition to documenting a number of large loop closures useful for developing ma...

Wildlife-vehicle collisions (WVC) have increased and now there is a world-wide problem related to significant mortality of wildlife, habitat fragmentation, change in behavior and even disappearance of local endangered populations. Along with these deleterious effects on wildlife, WVC can also result in injuries and deaths of humans. During the three-year monitoring, a total of 7,495 wildlife-ve...

Object detection and classification is challenging problem for vision-based intersection monitoring since traditional motion-based techniques work poorly when pedestrians or vehicles stop due to traffic signals. In this work, we present a method for vehicle and pedestrian recognition at intersections that benefits from both motion and appearance cues in video surveillance. Vehicle and pedestria...