Hemifacial spasm is a condition that may severely reduce patients' quality of life. Microvascular decompression is the neurosurgical treatment of choice. The objective of this work was to describe the efficacy and morbidity of microvascular decompression for hemifacial spasm, evaluate the long-term efficacy on the quality of life and investigate prognostic factors for failure of the procedure. ...

A priori, a common receptor induced in tumor microvessels, cancer cells and cancer stem-like cells (CSCs) that is involved in tumor angiogenesis, invasiveness, and CSC anoikis resistance and survival, could underlie contemporaneous coordination of these events rather than assume stochasticity. Here we show that functional analysis of the dual endothelin1/VEGFsignal peptide receptor, DEspR, (for...

La plupart des fractures per et sous trochantériennes consolident après une ostéosynthèse par clou gamma. Néanmoins, dans certaines situations notamment chez les sujets âgées avec une qualité osseuse médiocre un démontage du matériel peut survenir. Celui-ci est suspecté devant une recrudescence de la douleur et l'impotence fonctionnelle totale du membre inférieur. La confirmation diagnostic se ...

OBJECTIVES To present a case of central venous line misplacement with vasculo-pulmonary fistula and severe respiratory consequences in a newborn. To review the literature concerning respiratory and non-respiratory complications related to the introduction of percutaneously placed central venous lines in children. REPORT Evaluative and diagnostic data were described after patient chart review....

Injuries of the carpometacarpal joints of the long fingers are infrequent and go often unnoticed if a thorough clinical exploration and complete radiological assessment is not carried out. The overall frequency of carpometacarpal joints injuries is of 1-2% among trauma of the wrist and the carpus. These are normally secondary to high energy trauma (such as a car or a motorbike accidents). Among...

Vascular endothelial growth factor (VEGF) is a key regulator of vasculo- and angiogenesis. Earlier studies demonstrated a permeability-increasing effect of VEGF in skin tests, leading to its other name, vascular permeability factor. We wondered whether VEGF-induced hyperpermeability was a direct effect of VEGF on endothelial cells and studied the permeability of human and porcine endothelial ce...

L'ostéome ostéoïde de l'apophyse coronoïde est exceptionnel, pose des problèmes diagnostiques et thérapeutiques. La douleur représente le maître symptôme. La perte d'extension complète est classique, cependant celle de la pronation et supination est très rare. Le scanner constitue l'examen radiologique de référence à condition de réaliser des coupes fines. La résection monobloc à foyer ouvert c...

The concept that oxidative stress contributes to the development of human preeclampsia has never been tested in genetically-defined animal models. Homozygous deletion of catechol-O-methyl transferase (Comt-/-) in pregnant mice leads to human preeclampsia-like symptoms (high blood pressure, albuminurea and preterm birth) resulting from extensive vasculo-endothelial pathology, primarily at the ut...

The heart remodels myocardial tissue in physiological and pathological response. The cell-extracellular matrix (ECM) interaction provides not only structural and mechanical support but also important biological signaling during tissue remodeling. Among various ECM molecules, tenascin-C (TNC) is well known as a regulator of multiple cellular functions during embryogenesis, wound healing or cance...

OBJECTIVE To report on four patients with Behçet's disease associated with endomyocardial fibrosis involving the right or the left ventricle. METHODS Charts of more than 350 patients with Behçet's disease were reviewed. Endomyocardial fibrosis was confirmed because of cardiac failure in three patients and incidentally discovered by histological examination of an operative specimen in one pati...