Freeze-drying is a low-pressure, low-temperature condensation pumping process widely used in the manufacture of pharmaceuticals for removal of solvents by sublimation. Key performance characteristics of a freezedryer condenser are largely dependent on the vapor and ice dynamics in the low-pressure environment. The main objective of this work is to develop a modeling and computational framework ...

A new element- and chemical bond-dependent GE-EoS model(SRK-UNICAC) is proposed to consider the deviation of vapor liquid phases from ideal state. The SRK-UNICAC model combines UNICAC SRK cubic equation It uses original interaction parameters this calculate GE. predicted vapor-liquid equilibria for 87 binary systems under low- medium-pressure conditions, 12 high-pressure 14 ternary systems; a c...

In this paper, a genetic algorithm (GA) has been used to predict the vapor pressure of pure organic compounds based on Riedel equation. Initially, the coefficients of Riedel equation were optimized. Then, a new term was added to the original Riedel equation to reduce error of the model in prediction of vapor pressures of pure materials. 110 components at two different pressures (10 and 100 kPa)...