نتایج جستجو برای: v notch
تعداد نتایج: 321822 فیلتر نتایج به سال:
OBJECTIVE Withaferin A, a natural withanolide, has shown anti-cancer properties in various cancers including breast cancer, but its effects in ovarian cancer remain unexplored. Notch 1 and Notch3 are critically involved in ovarian cancer progression. We decided to examine the effects of Withaferin A in ovarian carcinoma cell lines and its molecular mechanism of action including its regulation o...
Impact toughness of a gas tungsten arc welded Ti /6Al /4V alloy butt-joint was evaluated at room temperature using standard Charpy V-notch specimens. The Charpy specimens were prepared with notch roots located either in the parent metal, in the heataffected zone (HAZ), or in the weld metal. Optical metallography and Vickers microhardness test showed that the weld metal has the coarsest grains a...
An effective technique for mixer LO harmonic rejection in a SAW-less wideband receiver front-end is proposed. The proposed technique provides a tunable notch that can be placed at any frequency like mixer LO harmonics, to avoid the aliasing in baseband after mixing. An analog LC notch is used in a cascode transconductor, and it can reject one of the 3rd or 5th harmonics. T...
In this research, rotating bending fatigue test at minimum to maximum stress ratio of R=-1 was used for investigating the fatigue behavior of Ti-6Al-4V alloy. Both smooth and notched specimens, with elastic concentration factor, kt, of approximately 3.6 and 4.1 were used for this purpose.In addition, the effect of variation in ultimate tensile strength, UTS, on the fatigue behavior of this allo...
The objective of this study is to characterise grade R4 steel manufactured by ingot casting that used as the raw material for production offshore mooring chains. Rolled bars have been selected and metallographic analyses micro hardness, tensile Charpy V-notch impact tests performed. Tensile also carried out on links from same steel. Based results presented, influence rolling reduction ratio coo...
1. Abstract 2. Introduction 3. Notch signaling pathway 3.1. Notch receptors and ligands 3.2. Notch signaling activation 3.3. Notch signaling targets 4. Notch signaling in tumorigenesis 4.1. Cell proliferation 4.2. Cell survival (apoptosis evasion) 4.3. Angiogenesis 4.4. Cell invasion and metastasis 4.5. Notch and viral oncogenes 4.5.1. EBV viral protein EBNA2 and Notch 4.5.2. HPV viral protein ...
The Notch signaling pathway governs many distinct cellular processes by regulating transcriptional programs. The transcriptional response initiated by Notch is highly cell context dependent, indicating that multiple factors influence Notch target gene selection and activity. However, the mechanism by which Notch drives target gene transcription is not well understood. Herein, we identify and ch...
To solve the problem of large torque ripple interior permanent magnet synchronous motor (IPMSM), rotor surface notch design method was used for V-type IPMSM. In order to accurately obtain optimal parameter values improve performance motor, this paper takes output capacity and as optimization objectives, proposes a multi-objective layered based on hierarchical combined with Taguchi response (RSM...
This study investigated the roles of Notch‑1 in colorectal carcinoma, to assess the mechanisms. The expression of Notch‑1 and its ligand-Jagged1 was detected in human colorectal carcinoma, colorectal adenoma, paracancerous tissue and normal colorectal tissue by immunohistochemistry. Colorectal carcinoma cell lines were utilized to confirm the expression of Notch‑1 in colorectal carcinoma cells....
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید