Systemic lupus erythematosus (SLE) can involve many parts of the eye, including the eyelid, ocular adnexa, sclera, cornea, uvea, retina and optic nerve. Ocular manifestations of SLE are common and may lead to permanent blindness from the underlying disease or therapeutic side effects. Keratoconjunctivitis sicca is the most common manifestation. However, vision loss may result from involvement o...

3H labelled cyclosporin A (CS-A) eye drops (2% in castor oil) were applied in rabbits. When a single drop of 10 microliters was given CS-A reached a maximal concentration of 900-1400 ng/ml in the cornea 6 hr after application and then slowly decreased. A substantial level of 600-900 ng/ml was still present after 48 hr. When corneas were analysed for their cellular compartments, 67% of CS-A was ...

We report a case of post-streptococcal uveitis mainly presenting with bilateral recurrent retinal vasculitis in Korea. A 14-year-old Asian female presented with decreased visual acuity of 20 / 30 in the right eye and 20 / 25 in the left eye. The patient had a history of glomerulonephritis nine months before onset of uveitis. The manifestation of uveitis was predominantly retinal vasculitis. We ...

1. Marigo FA, Finger PT, McCormick SA, et al. Iris and ciliary body melanomas. Arch Ophthalmol. 2000;118:1515-1521. 2. SunbaMS,RahiAH,MorganG.Tumorsof theanterior uvea, I: metastasizing malignant melanoma of the iris. Arch Ophthalmol. 1980;98:82-85. 3. Planten JT. An unnecessary mistake. Ophthalmologica. 1970;160:369-371. 4. GrossniklausHE,BrownRH,StultingRD,etal. Iris melanomaseeding througha ...

are reported in the literature and only one of them is a ciliary body neurilemmoma. This is not correct, because according to Shields et al.2 (not cited) the reported cases of neurilemmoma are eight at least (associated and unassociated with neurofibromatosis), and two ofthem affected the ciliary body. Secondly, I would point out that in the case reported a fine needle aspiration biopsy could b...

The classical model of metastasis is that tumor cell dissemination occurs late in tumor development, after the primary tumor has grown, and that only then will tumor cells invade the local tissue, enter the blood or lymphatic vessels, and colonize new sites to cause metastases. However, evidence increasingly indicates that single tumor cells spread to distant sites much earlier than previously ...

Detection of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) in donor eyes was performed. DNAs were extracted from the uvea, and they were amplified using the polymerase chain reaction (PCR). Amplified viral DNAs were detected with liquid hybridisation and chemiluminescent assay in which no radioactive materials were used. This method was shown to have a...

Intraocular tumors are rare in the dog. Of the reported neoplasms, melanomas are the most common. These tumors characteristically arise in the anterior uvea and secondarily infiltrate posteriorly into the choroid and/ or anteriorly into the corneoscleral region. Advanced tumors may extend extraocularly. In the dog, isolated choroidal melanomas are extremely uncommon; to the authors' knowledge, ...

Malignant melanoma is one of the few malignancies that are well known for unusual behavior. Primary malignant melanoma usually originates from squamous epithelium of skin, mucous membranes, retina, and uvea. Although melanoma can metastasize to any part of the body, including biliary tract, primary malignant melanoma of bile ducts is an extremely rare entity. We present a 52-year-old man who pr...

Non-neoplastic inflammatory pseudotumors have been reported to arise at extraocular sites within the orbit" as well as in the posterior uveal tract."* Since their clinical appearance was indistinguishable from that of a malignant melanoma of the choroid, psuedotumors presenting as intraocular masses have been treated by enucleation and their true nature was not apparent until histologic examina...