نتایج جستجو برای: uterine nk cell
تعداد نتایج: 1723402 فیلتر نتایج به سال:
background: although there is convincing data in support of the effectiveness of hyperthermia in tumor therapy, the molecular mechanisms underlying the clinical effects of hyperthermia are still poorly understood. objective: to investigate natural killer (nk) cell cytotoxicity against heat-treated sw-872 and hela tumor cell lines. methods: nkg2d ligands and hla class i transcription were examin...
BACKGROUND Increased expression of killer cell inhibitory receptors (KIRs) has been found on natural killer (NK) cells in peritoneal fluid in women with endometriosis. In this study, we tried to measure the expression of KIRs on NK and T cells in women with adenomyosis, in an attempt to find the possible role of KIRs in the development of adenomyosis. METHODS A total of 10 women with adenomyo...
Background: Cancer is a public health emergency. It has a high mortality rate despite numerous studies on pharmaceutical therapies. Chimeric antigen receptor-natural killer (CAR-NK) cells are promising immunotherapy that could be used to treat cancer, especially leukemia. However, the evidence is still unclear. Thus, this systematic review aims to summarize the evidence regarding the use of CAR...
Inborn errors of DNA repair or replication underlie a variety of clinical phenotypes. We studied 5 patients from 4 kindreds, all of whom displayed intrauterine growth retardation, chronic neutropenia, and NK cell deficiency. Four of the 5 patients also had postnatal growth retardation. The association of neutropenia and NK cell deficiency, which is unusual among primary immunodeficiencies and b...
The base of this study has been demonstrated the use of different drugs and dosages on different tumour cell lines and finally the effect of these drugs on natural killerllimphokine activated killer (NK/LAK) Killing. Tumour cells as target , mononeuclear cell activated with inter leukin-2(LAK) as effector, anti cancer drugs like tamoxifen , pentoxifylline , cycloheximide and cisplatin as stimul...
Background: Perforin is known to be important in cytolytic activity mediated by natural killer (NK) cells. Objective: To study the relationship between the efficiency of NK and lymphokine-activated killer (LAK) cells activity, and the expression of perforin and HLA class I molecules. Methods: LAK cells were generated by in vitro culturing of human peripheral blood lymphocytes (PBLs) in the ...
background: perforin is known to be important in cytolytic activity mediated by natural killer (nk) cells. objective: to study the relationship between the efficiency of nk and lymphokine-activated killer (lak) cells activity, and the expression of perforin and hla class i molecules. methods: lak cells were generated by in vitro culturing of human peripheral blood lymphocytes (pbls) in the ...
background: chronic fatigue syndrome (cfs) is a complex condition involving severe fatigue and disabling musculoskeletal and cognitive symptoms. we reported that 6, 12 and 24 months following infectious mononucleosis (im), 13%, 7% and 4% of adolescents, respectively, met criteria for cfs. whether endocrinologic or immunologic dysfunction accompanies cfs is unclear. objectives: to determine if s...
Background: Umbilical cord blood (UCB) is an alternative source of hematopoietic stem cell transplantation (HSCT), used in Leukemia treatment. CD26+ cells, a fraction of CD34 positive cells, are a major population of UCB cells which negatively regulate the in vivo homing and engraftment of HSCs. CD26 is highly expressed in various cells such as HSCs, immune cells, fibroblasts, and epithelial ce...
NK cells are important in protecting against viral infections, and they may regulate the immune response. They are activated by hematopoietic blasts and pose a barrier to bone marrow transplantation. They are also abundant in the pregnant uterine decidua, although their role there is unknown. NK cells are normally inhibited from responding to host cells by inhibitory receptors that recognize se...
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