In serum obtained from 28 women before, during, and after normal labor and delivery, creatine kinase activity was seen to be distinctly elevated immediately after labor and 24 h later, but had returned to normal six weeks later. In most cases the increase was due to the MM isoenzyme and was attributed to skeletal-muscle damage associated with labor. In 15 cases, the BB isoenzyme was observed, a...

Dysmenorrhea is directly related to elevated PGF(2alpha) levels. It is treated with nonsteroid antiinflammatory drugs (NSAIDs) in Western medicine. Since NSAIDs produce many side effects, Chinese medicinal therapy is considered as a feasible alternative medicine. Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) has been used as a traditional Chinese medicine for treating dysmenorrhea. However,...

OBJECTIVE The purpose of this case series was to retrospectively examine records of cases with uterine rupture in pregnancies following myomectomy and to describe the clinical features and pregnancy outcomes. METHODS This study was conducted as a multicenter case series. The patient databases at 7 tertiary hospitals were queried. Records of patients with a diagnosis of uterine rupture in the ...

The electrical excitability of uterine smooth muscle cells is a key determinant of the contraction of the organ during labor and is manifested by spontaneous, periodic action potentials (APs). Near the end of term, APs vary in shape and size reflecting an ability to change the frequency, duration and amplitude of uterine contractions. A recent mathematical model quantified several ionic feature...

The impact of colitis on uterine contractility and estrous cycle was investigated after intracolonic administration of 2,4,6-trinitrobenzenesulfonic acid (TNBS) in rats. Colitis severity was assessed by macroscopic damage scoring (MDS) 4 days after TNBS, and myeloperoxidase (MPO) activity was measured in both colon and uterus of control and colitic rats. Estrous cycle stages were determined by ...

uterine inversion is shortly described as the indentation and depression of the fundic area extending downwards up to the different levels of the birth canal till vaginal opening. clinical diagnosis of uterine inversion is difficult due to its non-specific symptoms and physical examination. ultrasonography is the most practical modality for radiological evaluation, but it is inadequate to deter...

Uterine fibroma, leiomyoma or myoma, is both the most common solid tumor, as well as the most frequent smooth muscle tumor in women [1, . It occurs in about 50% of women of reproductive age, and although many leiomyomas are asymptomatic, they may well lead to perturbing symptoms such as heavy menstrual bleeding, pelvic pressure symptoms and infertility . Consequently, this benign uterine tumor ...

Lipopolysaccharide (LPS), produced by gram-negative bacteria, mediates vasodilatation, changing the action of contractile smooth muscle by increasing expression of nitric oxide synthase and prostaglandin. For the first time we demonstrate, by immunohistochemical methods, that administration of LPS to pregnant mice causes alpha-actin-mediated down-regulation of contractile filaments in uterine b...

Introduction/Background* Benign metastasizing leiomyoma (BML) is a rare benign condition involving the extra-uterine spread of smooth muscle cells with histological, immunological, and molecular patterns similar to those uterine leiomyomas. Due uncommon nature disease, diagnosis treatment very challenging. There are no current standardized guidelines for BML but usually treated combina...

Uterine leiomyoma are benign mesenchymal solid tumors originating from smooth muscle cells during the fertile stage of life. There are various factors that are associated to underlie the development and incidence of these myomas. A number of chromosomal alterations and gene mutations are responsible for the leading cause of uterine leiomyoma: the most common of which include translocation on ch...