Apple (Malus × domestica Borkh.), a popular and widely cultivated fruit world-wide, contains bioactive triterpenes and phenolic compounds with potentially valuable pharmacological functions. This thesis investigated the effects of pre-harvest and postharvest factors on concentrations of these bioactive compounds in apples. It also studied the effect of ozone treatment, before or during storage,...

Ursolic acid is a triterpenoid compound in the plant kingdom and has important biological functions. In this study, ursolic contents of nine herbs including Anethum graveolens (dill), Camellia sinensis L. (green tea), Lepidium sativum (garden cress), Ocimum basilicum (sweet basil), Petroselinum crispum (parsley), Rosmarinus officinalis (rosemary), Salvia (sage), Thymus vulgaris (thyme) Urtica d...

Our previous results elucidated that the leaves of Eriobotrya japonica possessed the potential to suppress ovariectomy-induced bone mineral density deterioration, and ursolic acid, the major bioactive component in these leaves, suppressed the osteoclast differentiation. The aim of this study was to discover more candidates for development of novel antiosteoclastogenesis agents from the leaves o...

The present research aimed to isolate the non-polar secondary metabolites that produce the vasodilator effects induced by the dichloromethane extract of Prunus serotina (P. serotina) fruits and to determine whether the NO/cGMP and the H2S/KATP channel pathways are involved in their mechanism of action. A bioactivity-directed fractionation of the dichloromethane extract of P. serotina fruits led...

(1) Background: In China and South Asia, Alstonia scholaris (Apocynaceae) is an important medicinal plant that has been historically used in traditional ethnopharmacy to treat infectious diseases. Although various pharmacological activities have been reported, the anti-lung cancer components of A. scholaris have not yet been identified. The objective of this study is to evaluate the active comp...

Oleanolic acid and ursolic acid are pentacyclic triterpenoids isolated from a variety of medicinal plants, which have antibacterial activity. Listeria monocytogenes is a Gram-positive facultative pathogen, being the causative agent of listeriosis. The present study was carried out to evaluate the in vitro effect of sub-inhibitory concentrations of both triterpene acids on the pathogenicity dete...

From an EtOAc extract of Dracocephalum subcapitatum, five flavonoids, calycopterin, xanthomicrol, isokaempferide, luteolin and apigenin, together with five terpenoids, oleanolic acid, ursolic acid, geranial, neral and limonene-10-al, were isolated. Among them, citral and limonene-10-al were the most effective components against epimastigotes of Trypanosoma cruzi, the parasitic agent of Chagas d...

objective(s):the current study was aimed to determine the bioactive constituents and biological effects of the crataegus monogyna ethanolic extracts from bark, leaves and berries on hypercholesterolemia. materials and methods: oleanolic acid, ursolic acid, quercetin and lupeol concentrations were quantified by hplc. total phenol content and radical scavenging activity of extracts were also meas...