A series of unsymmetrical distyryl BODIPYs have been prepared which function as highly potent photosensitisers with in vitro IC(50) values as low as 15 nM. Their cellular uptake, subcellular localisation and photocytotoxicity depend greatly on the styryl substituents.

A new method for the synthesis of unsymmetrical calix[4]arenes is described which involves the reaction of a diyne with a bis-carbene complex of chromium. This synthesis of calixarenes is unique in that it involves the formation of two of the four benzene rings of the calixarene and the macrocyclic ring of the calixarene in the same step. Thus, two of the four benzene rings of the calixarene ar...

We report the interfacial properties of a new fluorocarbon-hydrocarbon hybrid surfactant [OH(CH2)11N(C2H4)2(CH2)2(CF2)5CF3 I, or FHUB], which has a fluorocarbon chain as well as a w-hydroxyalkyl chain. This new hybrid surfactant has properties that are different than classical hydrocarbonand fluorocarboncontaining surfactants. This difference is created by combining a fluorocarbon chain and the...

A robust N-nucleophilic 1,3-N,O-dipole equivalent reacts with unsymmetrical internal alkynes under gold catalysis. Conjugation from a remote nitrogen lone pair enables and controls this convergent and highly regioselective process.

Fmoc-protected amine derivatives of Protoporphyrin IX were synthesized by two original methods using solid-phase chemistry. The new compounds represent unsymmetrical scaffolds suitable for the generation of a large range of peptidic porphyrin derivatives through SPPS strategy.

A convenient methodology for the highly stereoselective synthesis of unsymmetrical (1E,3E)-1,4-disubstituted 1,3-dienes based on palladium-catalyzed Hiyama cross-coupling reaction of 1-(triethoxysilyl)-substituted buta-1,3-dienes with aryl iodides is reported.

Several unsymmetrical heterobiaryls have been synthesized through palladium-catalyzed cross-coupling reactions of lithium triorganozincates. The latter have been prepared by deprotonative lithiation followed by transmetalation using non hygroscopic ZnCl2·TMEDA (1/3 equiv).

Three mononuclear half-sandwich iron() (S = 1⁄2) complexes [(L/L)FeCl3] H2O (1/2) and [(L)Fe(N3)3] (3) have been synthesized and their properties investigated [L = methyl[2-(2-pyridyl)ethyl](2-pyridylmethyl)amine; L = N-methyl-N,N-bis(2-pyridylmethyl)amine]. X-ray structural analysis revealed that in 3 the FeN6 unit is attained by co-ordination of three nitrogens of facially capping L and th...

Direct access to unsymmetrical urea derivatives via copper catalysed C-H/N-H coupling of formamides with amines has been developed at room temperature. This protocol is also applied to the synthesis of chiral urea derivatives.