To ensure that a drug product will meet standards for identity, strength and stability as specified in the United States Pharmacopedia and National Formulary (USP/NF), it needs to pass a number of tests such as the content uniformity test and dissolution test at various stages of the manufacturing process. The sponsors usually have in-house specification limits based on some lower bounds of the...

The objective of this study was to evaluate whether Doppler ultrasound (DUS) is of additional value to gray-scale ultrasound (GSUS) in predicting the benign or malignant nature of thyroid nodules. A total of 1,502 solid thyroid nodules ≥ 10 mm were evaluated. Suspicious vascularity (predominantly or exclusively central blood flow) was observed in only 5% of the nodules. This finding showed 96% ...

BACKGROUND We aimed to evaluate the validity of duplex ultrasonography (DUS) using a microconvex array transducer (MAT) with enhanced flow imaging (EFI) for visualization of the distal, internal carotid artery (ICA) and the accurate assessment of ICA stenosis. METHODS Patients who underwent both DUS and digital subtraction angiography (DSA) were registered for this study. DUS was performed by...

BACKGROUND AND PURPOSE The purpose of this work was to review and compare published data on the diagnostic value of duplex ultrasonography (DUS), MR angiography (MRA), and conventional digital subtraction angiography (DSA) for the diagnosis of carotid artery stenosis. METHODS We performed a systematic review of published studies retrieved through PUBMED, from bibliographies of review papers, ...

Using Discounted Utterances (DUs) in spontaneous conversation by applying text mining technology, extraction, and evaluation, we focused on DUs where values were buried in previous conversations. We discovered DU potentials by reconsidering them through human-computer interaction. Onlinechat experiments clarified DU features and demonstrated our system’s importance. We found DUs involving (1) e...

PURPOSE A native vessel is preferable to an artificial graft for dialysis access. Duplex ultrasound (DUS) is noninvasive, cost-effective modality to evaluate the vessels for dialysis. The purpose of this study was to compare the rates of utilization of native vessels after preoperative imaging with DUS and contrast venography (CV). MATERIALS AND METHODS A retrospective review was performed on...

Brassica chinensis varieties are mostly consumed as vegetables. In order to assess utility of microsatellite markers for testing distinctness, uniformity and stability of B. chinensis varieties, we used nine polymorphic microsatellite marker loci (with a total of 131 alleles) to evaluate four open pollinated and four hybrid varieties of B. chinensis. Each variety was represented by 48 randomly ...

BACKGROUND AND PURPOSE To estimate clinical roles of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) versus angiography and ultrasonography in carotid plaque characterization. METHODS We characterized two groups of patients with recently (<1 month) symptomatic (n=14; age=71.8±8.6 years, mean±SD) or chronic (n=13, age=68.9±9.0 years) carotid stenosis using a battery of imaging ...