PURPOSE KH902 is a fusion protein which combines ligand binding elements taken from the extracellular domains of vascular endothelial growth factor (VEGF) receptors 1 and 2 and the Fc portion of IgG1. This study is designed to examine the inhibitory effect of KH902 in the choroidal neovascularization (CNV) monkey model. METHODS The binding affinity with VEGF was measured by using the human VE...

OBJECTIVE To confirm the effect of the endothelial protein receptor gene (PROCR) haplotypes H1 and H3 on venous thromboembolism (VTE), to study their effect on endothelial protein C receptor (EPCR) expression in human umbilical vein endothelial cells, and to investigate the functionality of H1 tagging single-nucleotide polymorphisms in an in vitro model. APPROACH AND RESULTS Protein C (PC), a...

Abstract The study has aimed to investigate and determine the anatomical position, shape, size, histological features of ductus venosus, its role as a shunt in fetal circulatory system domestic ruminants. research was conducted on 19 bovine, 11 sheep 5 goat fetuses, aborted at late stage pregnancy or deceased just after delivery. general anatomy venosus investigated by in-situ dissection corros...

Umbilical catheter placement is frequently used in the neonatal intensive care unit. Umbilical vein is a very useful venous route to the usage of drugs, intravenous fluids and to obtain blood samples. It is a lifesaver for an emergency state in neonates. This application has several complications such as sepsis, hepatic injury, extravasation, cardiac tamponade, air embolism. We present a glutea...

Intrauterine, intraperitoneal transfusion is associated with a poor survival rate in fetuses with hydrops and low gestational age. A method of direct fetal intravenous transfusion was used in two fetuses. One fetus with severe rhesus haemolytic disease was given transfusions in the 29th and 30th weeks of gestation, using an ultrasound-guided needle through the hepatic part of the umbilical vein...

In serial sagittal sections of a fetus on week 9 (crown-rump length, 36 mm), we incidentally found absence of the usual portal vein through the hepatoduodenal ligament. Instead, an anomalous portal vein originated behind the pancreatic body, crossed the lesser sac and merged with the upper part of the ductus venosus. During the course across the lesser sac, the vein provided a deep notch of the...

BACKGROUND As a main cause of mortality in developed countries, Coronary Artery Disease (CAD) is known as silent killer with a considerable cost to be dedicated for its treatment. Coronary Artery Bypass Graft (CABG) is a common remedy for CAD for which different blood vessels are used as a detour. There is a lack of knowledge about mechanical properties of human blood vessels used for CABG, and...

During a study of babies with respiratory distress syndrome (RDS) and of the effects of intravenous bicarbonate and laevulose on glycogen reserves of the newborn (Scott, 1965), it was found that 2 babies developed complications arising out of treatment. One had an umbilical vein thrombosis with large pulmonary embolus. The other developed umbilical sepsis with a thrombophlebitis and pyaemia. It...

High-content screening of kinase inhibitors is important in order to identify biogenesis and function mechanisms of subcellular organelles. Here, we present a human kinome siRNA high-content screen on primary human umbilical vein endothelial cells, that were transfected by electroporation. The data descriptor contains a confocal fluorescence, microscopic image dataset. We also describe an open ...