The clinical and pathological features of five cases of calcification of umbilical cord vessels were reviewed. Two distinct lesions were identified: calcification could produce either sclerosis of the wall or obliteration of the lumen. In three cases there was calcification within the media and adventitia of the umbilical arteries, with extension into Wharton's jelly in one case. The pathogenes...

Our previous papers demonstrated that preeclampsia – associated accumulation of collagen and proteoglycans in the umbilical cord tissues is a result of increased biosynthesis and decreased degradation of these components. Metalloproteinases are enzymes engaged in degradation of collagen and protein cores of proteoglycans, including those which bind peptide growth factors. Western Immunoblot met...

In this paper we report that the integrin complex alpha 1/beta 1, a laminin/collagen receptor, is expressed on cultured foreskin microvascular endothelium, but is absent on endothelial cells from large vessels such as the aorta and umbilical and femoral veins. The restricted expression of integrin alpha 1/beta 1 to microvascular endothelium was also demonstrated in vivo, by immunohistochemical ...

BACKGROUND We report on a case of an impar umbilical artery (IUA) in an 18-year-old woman. CASE PRESENTATION The aorta branched off at level L2 into a ventral IUA and a dorsal aorta. The strong IUA produced the inferior mesenteric artery (IMA), the renal artery of a left-sided duplex kidney, and the right-sided ovarian artery before it turned to the right to merge into the right common iliac ...

BACKGROUND It has been established that presence of lean umbilical cord with reduced Wharton's jelly in sonographic scans is a fetal marker for risk of small for gestational age at birth. With improvement of ultrasound techniques, more studies have been investigating the alterations of the umbilical cord on pregnancy outcomes. OBJECTIVES To determine the reference ranges of the umbilical cord...

BACKGROUND One previous, preliminary study reported that the length of the umbilical cord at birth is related to the risk of developing chronic rheumatic heart disease in later life. We sought to replicate this finding. DESIGN Prospective, population-based birth cohort. METHODS We traced 11,580 individuals born between 1915 and 1929 in Uppsala, Sweden. We identified cases with a main or sec...

Background: Doppler ultrasonography enables the investigation of vascular blood flow indexes in gestational assessment, being able to detect resistances that can affect fetal and maternal circulation, such as cases placental insufficiency, associated with cerebral oxygenation deficit distress. The study aims assume hemodynamically normal values final third gestation bitches, umbilical, uteropla...