OBJECTIVE Recent evidence suggests that the AMP-activated protein kinase (AMPK) is an important therapeutic target for diabetes. The present study was conducted to determine how AMPK activation suppressed tyrosine nitration of prostacyclin synthase in diabetes. RESEARCH DESIGN AND METHODS Confluent human umbilical vein endothelial cells (HUVECs) or mice were treated with 5-amino-4-imidazole c...

An uncoupling protein (UCP) was identified in mitochondria from Candida parapsilosis (CpUCP), a non-fermentative parasitic yeast. CpUCP was immunodetected using polyclonal antibodies raised against plant UCP. Activity of CpUCP, investigated in mitochondria depleted of free fatty acids, was stimulated by linoleic acid (LA) and inhibited by GTP. Activity of CpUCP enhanced state 4 respiration by d...

The expression of alternative oxidase (Aox) and uncoupling proteins (Ucp) was investigated during ripening in mango (Mangifera indica) and compared with the expression of peroxisomal thiolase, a previously described ripening marker in mango. The multigene family for the Aox in mango was expressed differentially during ripening. Abundance of Aox message and protein both peaked at the ripe stage....

State space and plan space planning approaches have traditionally been seen as fun-damentally different and competing approaches to domain-independent planning. Wepresent a plan representation and a generalized algorithm template, called UCP, for unify-ing these classical planning approaches within a single framework. UCP models planningas a process of refining a partial plan. T...

BACKGROUND Previous studies on breast cancer (BC), underarm cosmetic products (UCP) and aluminum salts have shown conflicting results. We conducted a 1:1 age-matched case-control study to investigate the risk for BC in relation to self-reported UCP application. METHODS Self-reported history of UCP use was compared between 209 female BC patients (cases) and 209 healthy controls. Aluminum conce...

This paper discusses and optimizes an HMM/GMM based User-Customized Password Speaker Verification (UCP-SV) system. Unlike text-dependent speaker verification, in UCP-SV systems, customers can choose their own passwords with no lexical constraints. The password has to be pronounced a few times during the enrollment step to create a customer dependent model. Although potentially more “user-friend...

The purpose of this study was to determine whether chronic cold exposure would increase the aerobic capacity of skeletal muscle in UCP-dta mice, a transgenic line lacking brown adipose tissue (BAT). Wild type and UCP-dta mice were acclimated to either warm (23 °C), or cold (4 °C) conditions. Cold increased muscle oxidative capacity nearly equivalently in wild-type and UCP-dta mice, but did not ...

PURPOSE To evaluate the clinical outcome of umbilical cord patch (UCP) transplantation for deep corneal ulcers with perforations and descemetoceles. METHODS In this retrospective, noncomparative, interventional case series, 11 eyes of 11 patients with corneal perforation or descemetocele were included. The thickness and microstructure of UCP were measured. All eyes were treated with UCP and a...