The tyrosine kinase inhibitors ST271, ST638 and erbstatin inhibited phospholipase D (PLD) activity in human neutrophils stimulated by fMet-Leu-Phe, platelet-activating factor and leukotriene B4. These compounds did not inhibit phorbol ester-stimulated PLD, indicating that they do not inhibit PLD per se, but probably act at a site between the receptor and the phospholipase. In contrast, the prot...

BACKGROUND AND PURPOSE Serotonin is one of the most potent constrictors of cerebral blood vessels and is implicated in several pathological conditions, including migraine and cerebral ischemia. Recent evidence has suggested that tyrosine kinase is involved in vasocontractile responses. The objective of this study was to test the hypothesis that activation of tyrosine kinase contributes to serot...

Tyrosine kinases are one of the most important regulators for intracellular signal transduction related to inflammatory responses. However, there are no reports describing the effects of tyrosine kinases on neutrophil apoptosis induced by Entamoeba histolytica. In this study, isolated human neutrophils from peripheral blood were incubated with live trophozoites in the presence or absence of tyr...

The present study examined the levels of NMDA receptor NR2 subunit tyrosine phosphorylation in a rat model of inflammation and correlated it with the development of inflammation and hyperalgesia. Hindpaw inflammation and hyperalgesia were induced by intraplantar injection of complete Freund's adjuvant. Proteins from the spinal cord (L4-L5) were immunoprecipitated with anti-NR2A or anti-NR2B ant...

Background: Human epidermal growth factor receptor 2 (Her2) gene located in human chromosome17, encodes Her2 tyrosine kinase protein, and is overexpressed breast cancer cells. activated on phosphorylation of by adenosine triphosphate (ATP). Nonetheless, excessively partakes the development prognosis specific types aggressive cancers. Therefore, inhibition therapy primary target for treatment ca...

EGFR is a key player in the signalling cascades of various kinds cancers and tyrosine kinase inhibitors block signalling. Natural products have long been used as candidates for therapy management cancer. Violacein, bacterial pigment, has known its numerous biological applications such antimicrobial, antileishmanial, antiviral, well antitumoral. Computational studies concluded that it may activi...

Abstract BACKGROUND Glioblastoma is associated with dismal outcomes a survival of 15-18 months. A major challenge in glioblastoma the inability to effectively target glioma stem cells (GSCs) that have capacity for self-renewal. GSCs are resistant radiation and traditional chemotherapy agents. Ibrutinib first-in-class, potent, small-molecule tyrosine kinase inhibitor Bruton’s Tyrosine Kinase (BT...

Objective(s):Higher cellular reactive oxygen species (ROS) levels is important in reducing cellular energy charge (EC) by increasing the levels of key metabolic protein, and nitrosative modifications, and have been shown to damage the cardiac tissue of diabetic mice. However, the relation between energy production and heart function is unclear. Materials and Methods:Streptozotocin (STZ, 150 mg...

Since the era of tyrosine kinase inhibitor (TKI) therapy, there has been an increase in median survival chronic myeloid leukemia. Nevertheless, nowadays were several cases leukemia that are resistant to first-line TKIs, so second-line TKIs introduced. Assessment therapeutic response was performed using a complete peripheral blood examination, bone marrow aspiration cytogenetic and quantitative ...

The aim of this study was to determine the role of intracellular proteins in phagocytosis of opsonized Porphyromonas gingivalis by RAW264.7 cells, a murine macrophage-like cell line. This periodontopathogen was grown anaerobically and opsonized with an IgG2a murine monoclonal anti-P. gingivalis lipopolysaccharide antibody. RAW264.7 cells were preincubated with protein tyrosine kinase inhibitors...