conclusions we showed that in treatment of patients with unresectable hepatocellular carcinoma, tace significantly improved the disease and the overall survival rate. also, we introduce the tumor size, serum alp level, and number of liver involved segments as prognostic factors of the procedure. finally, tace can be recommended as the initial treatment for unresectable hcc patients. background ...

ObjectivesNon-small cell lung cancer (NSCLC) tumors harboring common (exon19del, L858R) and uncommon (e.g. G719X, L861Q) activating epidermal growth factor receptor (EGFR) mutations are best treated with EGFR tyrosine kinase inhibitors (TKI) such as the first-generation TKI erlotinib, second-generation afatinib or third-generation osimertinib. However, identifying these patients through biopsy ...

Objective(s)   Although photodynamic therapy is considered as a noninvasive method, most photosensitizers are susceptible to  ultrasound.  Therefore,  it  is  expected  that  the  combination of  two  activation  methods  might  have  a synergistic effect. This probable effect has been investigated in this study.   Materials and Methods   This  study  was  conducted  on  colon  carcinoma ...

Background: Irreversible electroporation (IRE) is a novel tumor ablation technique. IRE is associated with high electrical fields and is often reported in conjunction with thermal damage caused by Joule heating. For good response to surgery it is crucial to produce minimum thermal damage in both tumoral and healthy tissues named Non-Thermal Irreversible Electroporation(NTIRE). Non-thermal irrev...

abstract accumulation of gene changes and chromosomal instability in response to cellular dna damage lead to cancer. dna damage induces cell cycle checkpoints pathways. checkpoints regulate dna replication and cell cycle progression, chromatin restructuring, and apoptosis. checkpoint kinase 2 (chk2) is activated in response to dna lesions. atm phosphorylate chk2. the activated chk2 kinase can p...

ovarian mixed germ cell tumors consisting of endodermal sinus tumor and immature teratoma are very rare and have been reported only in a few case reports. here we report a rare mixed germ cell tumor of ovary which was consisted of endodermal sinus tumor and immature teratoma components with an unusual intraabdominal location. patient was a 21 years old girl with the chief compliant of abdominal...

Advanced melanoma is an aggressive form of skin cancer characterized by low survival rates. Less than 50% advanced patients respond to current therapies, and those that do respond, many present with tumor recurrence due resistance. The immunosuppressive tumor-immune microenvironment (TIME) remains a major obstacle in therapy. Adjuvant treatment modalities enhance anti-tumor immune cell function...