Abstract IL1? is a central mediator of inflammation. Secretion typically requires proteolytic maturation by the inflammasome and formation membrane pores gasdermin D (GSDMD). Emerging evidence suggests an important role for in promoting cancer progression patients, but underlying mechanisms are ill-defined. Here, we have shown key driving tumor two distinct mouse models. Notably, activation inf...

Introduction: It has been reported that platelets can eradicate tumor cells in vitro, although the mechanism of this effect has not been determined. The effect of platelets on the induction of apoptosis in tumor cells is largely unknown. Materials and methods: To investigate this effect, two human hematologic cell lines, K562 and Daudi, were independently faced with unstimulated and thromb...

Colorectal cancer (CRC) remains one of the deadliest malignancies worldwide despite recent progress in treatment strategies. Though immune checkpoint inhibition has proven effective for a number other tumors, it offers benefits only small group CRC patients with high microsatellite instability. In general, heterogenous cell groups tumor microenvironment are considered as major barrier unveiling...