نتایج جستجو برای: tumor associated macrophages

تعداد نتایج: 1906285  

2012
Heike Daldrup-Link Lisa M. Coussens

Tumor associated macrophages (TAMs) in breast cancers foster several aspects of tumor progression and metastasis, and represent a biomarker associated with an unfavorable clinical outcome. As new therapeutic agents selectively targeting leukocytes enter the clinic whose mechanism of action involves diminishing macrophage infiltration or presence in tumors, it becomes increasingly important to i...

Journal: :Brain research 2012
Clément David J Philip Nance Jacqueline Hubbard Mike Hsu Devin Binder Emma H Wilson

Glioblastoma multiforme is a very aggressive and common form of brain tumor. Current therapies consist of a combination of surgical removal, chemotherapy and radiation therapy. These drastic treatments still leave a current prognosis of median survival of less than 1 year. Lack of effectiveness of these treatments has left researchers looking for alternative forms of treatment. A significant al...

2010
Alessandra Mancino Toby Lawrence

Authors' A Marseille-L Correspon Parc Scien 33-0-4-91univ-mrs.fr

Journal: :Cancer Nanotechnology 2023

Abstract Background Tumor angiogenesis, immunosuppression, and progression are all closely correlated with the tumor microenvironment (TME). Immune evasion is supported by both M2 phenotype tumor-associated macrophages (TAMs) vascular aberrations in TME. TME reprogramming a promising therapeutic approach for treating tumors. Anti-angiogenesis has power to control polarization of macrophages, pr...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2008
Cheng-Han Lee Inigo Espinosa Suzan Vrijaldenhoven Subbaya Subramanian Kelli D Montgomery Shirley Zhu Robert J Marinelli Johannes L Peterse Neal Poulin Torsten O Nielsen Rob B West C Blake Gilks Matt van de Rijn

PURPOSE Macrophages are migratory cells that are frequently recruited to the site of tumors. Their presence is associated with poor clinical outcome in a variety of epithelial malignancies. The aim of this study is to examine the prognostic significance of tumor-associated macrophages in sarcomas. EXPERIMENTAL DESIGN Global gene expression profiling data of a series of soft tissue tumors were...

Journal: :Immunity 2014
Roy Noy Jeffrey W Pollard

The tumor microenvironment is a complex ecology of cells that evolves with and provides support to tumor cells during the transition to malignancy. Among the innate and adaptive immune cells recruited to the tumor site, macrophages are particularly abundant and are present at all stages of tumor progression. Clinical studies and experimental mouse models indicate that these macrophages generall...

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