Adoptive transfer of antigen-specific CD4(+) and CD8(+) T cells is one of the most efficient forms of cancer immunotherapy. However, the isolation of antigen-specific CD4(+) T cells is limited because only few tumor-associated helper epitopes are identified. Here, we used T cell antigen receptor gene transfer to target CD4(+) T cells against an MHC class I-presented epitope of a model tumor ant...

Tumor-assocla,ted antigens have been identified on a variety of human neoplasms. Each of these antigens may be able to serve as a target for an immune respOf.lse, the result of which would be eliminatjon of the tumor celL An essential component of this immune response is the presentation of antigen to potential effector cells. This can be accom­ plished via host professional antigen~presenting ...

Abstract The omentum, a visceral adipose tissue, is frequent site of metastasis for gastric and ovarian cancers. Advanced cancer almost always metastasizes to the omentum. Currently available therapies do not control tumor growth long-term there recurrence metastasis. In mice, cells injected intraperitoneally implant in omentum grow progressively despite tumor-specific CD8 T cells. lack effecti...

We have analyzed the regulation of viral transcription by the large tumor antigen in cells infected by several viable deletion and insertion mutants of polyomavirus. We find that deletion of the early promoter "TATA box" and associated large tumor antigen binding site has only a small effect on the balance of early and late mRNAs. Furthermore, transcription of a polyomavirus containing a hetero...

Objective(s): Apoptotic effect of apoptin has been demonstrated in numerous studies. However, its tumor specificity has been questioned by some reports. The aim of this study was to confine the expression of apoptin in the prostate tumor cells by inducing its gene expression under the control of a chimeric enhancer composing of prostate-specific membrane antigen (PSMA) and prostate-specific ant...

Adoptive cell therapy based on chimeric antigen receptor-engineered T (CAR-T) cells has proven to be life-saving for many cancer patients. However, its therapeutic efficacy so far been restricted only a few malignancies, with solid tumors proving especially recalcitrant efficient therapy. Poor intra-tumor infiltration by and “T dysfunction” due an immunosuppressive microenvironment are key barr...

Abstract T cell exhaustion is a major contributor to tumor immune invasion. The durability of an anti-tumor response in part determined by the persistence exhausted CD8 progenitors (Tpex) that reconstitute effector pool. While it has been reported Tpex are able survive without antigen, role TCR engagement regulating self-renewal during progression remains be fully explored. Here, we used Lewis ...