Immunophenotyping of the tumor microenvironment (TME) is essential for enhancing immunotherapy efficacy. However, strategies characterizing TME exhibit significant heterogeneity. Here, we show that endoplasmic reticular oxidoreductase-1α (ERO1A) mediates an immune-suppressive and attenuates response to PD-1 blockade. Ablation ERO1A in cells substantially incites anti-tumor T cell immunity promo...

OBJECTIVE To perform a systematic review of compliance with standardized terminology and reporting criteria for radiofrequency (RF) tumor ablation, proposed by the International Working Group on Image-Guided Tumor Ablation in 2003, in the published reports. MATERIALS AND METHODS Literature search in the PubMed database was performed using index keywords, PubMed limit system, and eligibility c...

Loco-regional treatments play a key role in the management of hepatocellular carcino‐ ma (HCC). Image-guided tumor ablation is recommended in patients with early-stage HCC when surgical options are precluded. Radiofrequency ablation is currently es‐ tablished as the standard method for local tumor treatment. Despite major advances in tumor ablation techniques the disease recurs in a high propor...

Approximately 25% of all oral cavity carcinomas involve the lips, and the primary management of these lesions is complete surgical resection. Loss of tissue in the lips after resection is treated with a variety of techniques, depending on the extension and location of the defect. Here we review highly accepted techniques of lip reconstruction and some of new trials with significant clinical res...

We report the first successful use of irreversible electroporation for the minimally invasive treatment of aggressive cutaneous tumors implanted in mice. Irreversible electroporation is a newly developed non-thermal tissue ablation technique in which certain short duration electrical fields are used to permanently permeabilize the cell membrane, presumably through the formation of nanoscale def...

PURPOSE To review complications related to percutaneous renal tumor ablation. MATERIALS AND METHODS Prospectively collected data related to renal radiofrequency (RF) ablation and cryoablation procedures performed from May 2000 through November 2010 were reviewed. This included 573 renal ablation procedures performed in 533 patients to treat 633 tumors. A total of 254 RF ablation and 311 cryoa...

BACKGROUND A ruptured hepatocellular carcinoma (HCC) is often fatal. In addition to surgery and transarterial embolization, radiofrequency ablation (RFA) might be another option for treating a ruptured HCC. Unfortunately, conventional RFA has a limited ablation zone; as such, it is rarely used to treat ruptured tumors. CASE PRESENTATION This case was a 60-year-old man who had a large, rupture...

Abstract Macrophage inflammatory protein-3, or MIP-3α, is a chemokine that highly expressed in gliomas, with expression progressively increasing tumor grade. It one of the top genes pseudopalisading and perinecrotic zones glioblastoma (GBM) as chemokine, can greatly influence tumor-immune interactions. The receptor for CCR6, found on variety GBM-infiltrating immune subsets such γδ T cells, conv...

Purpose: To evaluate the safety and midterm results of radiofrequency (RF) ablation for the treatment of renal cell carcinoma (RCC) in patients with von Hippel-Lindau (VHL) disease. Materials and methods: This study included 13 patients with VHL (8 women and 5 men; mean age: 35.5 years) and RCC. Each patient presented with 1-6 RCCs (mean: 2.4 ± 1.7) without extrarenal metastasis. The mean tumor...

OBJECTIVE The objective of this study was to evaluate the safety and therapeutic efficacy of percutaneous radiofrequency (RF) ablation for the treatment of hepatocellular carcinomas (HCCs) adjacent to the gallbladder with the use of internally cooled electrodes. MATERIALS AND METHODS We retrospectively assessed 45 patients with 46 HCCs (mean size, 2.2 cm) adjacent to the gallbladder (<or=1.0 ...