MEGAHIT is a NGS de novo assembler for assembling large and complex metagenomics data in a time- and cost-efficient manner. It finished assembling a soil metagenomics dataset with 252 Gbps in 44.1 and 99.6 h on a single computing node with and without a graphics processing unit, respectively. MEGAHIT assembles the data as a whole, i.e. no pre-processing like partitioning and normalization was n...

The recent breakthroughs in assembling long error-prone reads were based on the overlap-layout-consensus (OLC) approach and did not utilize the strengths of the alternative de Bruijn graph approach to genome assembly. Moreover, these studies often assume that applications of the de Bruijn graph approach are limited to short and accurate reads and that the OLC approach is the only practical para...

A method is developed to automatically generate an assembling procedure for an assembly. In this work, an assembly is described by its components and their relationship in an assembly, especially the mating conditions. From the mating conditions of the components, an assembling procedure is generated in two steps. First, a hierarchical structure of the assembly is generated. Second, an assembly...

Self-assembling peptide nanofiber scaffolds are an excellent material for applications such as tissue repair, tissue regeneration, instant stopping of bleeding, and slow drug release. We report a new self-assembling peptide D-EAK16 consisting purely of D-amino acids. D-EAK16 and L-EAK16 display mirror-image CD spectra at 20 degrees C. Like L-EAK16, D-EAK16 self-assembles into nanofibers, thus d...

We present a tile system for assembling a counter of width K and height N = 2 on top of a seed-row in optimum time Θ(N). Our counter works at temperature 2. Earlier known constructions either took sub-optimal time or required temperature 3. Using existing techniques, our system for assembling a counter from a seed row can be extended into a system for assembling an N × N square in optimum time ...