Background TT virus (TTV) hepatitis is an infectious disease which can have both hepatic and extrahepatic manifestations, and it is transmitted prevalently parenterally, and rarely by enteral way. The prevalence of TTV in donors in the USA is 1%, from 1.9-10% in Great Britain, in Japan 12%, in Thailand 7-30%, in Russia 10-20%, and in Brazil 62%. In patients with cryptogenic cirrhosis, the TTV w...

UNLABELLED The selection of liver transplantation (LT) candidates with hepatocellular carcinoma (HCC) is currently validated based on Milan criteria. The use of extended criteria has remained a matter of debate, mainly because of the absence of prospective validation. The present prospective study recruited patients according to the previously proposed total tumor volume (TTV; ≤115 cm(3) )/alph...

Many aspects of the life cycle of torquetenoviruses (TTVs) are essentially unexplored. In particular, it is still a matter of speculation which cell type(s) replicates the viruses and maintains the generally high viral loads found in the blood of infected hosts. In this study, we sequentially measured the TTV loads in the plasma of four TTV-positive leukemia patients who were strongly myelosupp...

background and aims: torque teno virus (ttv) is a dna virus that isolated from the serum of a japanese patient without a-g transfusion-transmitted hepatitis and other etiology. ttv is detectable in plasma and peripheral blood mononuclear cells, different body fluids and secretions such as stools, saliva, semen, vaginal fluid. the genome exhibits high diversity that has enabled the determination...

Hedgehog (Hh) molecules play critical roles during development as a morphogen, and therefore their distribution must be regulated. Hh proteins undergo several modifications that tether them to the membrane. We have previously identified tout velu (ttv), a homolog of the mammalian EXT tumor suppressor gene family, as a gene required for movement of Hh. In this paper, we present in vivo evidence ...

As the number of known exoplanets continues to grow, the question as to whether such bodies harbour satellite systems has become one of increasing interest. In this paper, we explore the transit timing effects that should be detectable due to an exomoon and predict a new observable. We first consider transit time variation (TTV), where we update the model to include the effects of orbital eccen...

Anellovirus is a recently created, floating genus of viruses. Torque teno virus (TTV), the type species in the genus, was first discovered in a human patient with a post-transfusion hepatitis of unknown aetiology. Recently, TTV genetically related to but distinct from those discovered in humans have also been found in animals, including pigs. The aims of this study were to estimate the prevalen...

TT virus (TTV) is a newly identified human DNA virus of the family Circoviridae. Its genome consists of six putative open reading frames (ORFs). TTV was isolated originally from a patient with cryptogenic hepatitis and the association of TTV with hepatitis has been studied extensively, while its significance in other diseases is unknown. To examine the pathogenicity of TTV, mice transgenic for ...