نتایج جستجو برای: ttl

تعداد نتایج: 685  

Journal: :PLoS ONE 2009
Séverine Marcos Julie Moreau Stéphanie Backer Didier Job Annie Andrieux Evelyne Bloch-Gallego

BACKGROUND During development, neuronal growth cones integrate diffusible and contact guidance cues that are conveyed to both actin and microtubule (MT) cytoskeletons and ensure axon outgrowth and pathfinding. Although several post-translational modifications of tubulin have been identified and despite their strong conservation among species, their physiological roles during development, especi...

2005
E. J. Jensen J. B. Smith L. Pfister J. V. Pittman E. M. Weinstock D. S. Sayres R. L. Herman R. F. Troy J. C. Wilson

Recent in situ measurements at tropical tropopause temperatures as low as 187 K indicate supersaturations with respect to ice exceeding 100% with little or no ice present. In contrast, models used to simulate cloud formation near the tropopause assume a supersaturation threshold for ice nucleation of about 65% based on laboratory measurements of aqueous aerosol freezing. The high supersaturatio...

Journal: :Electronics and Electrical Engineering 2012

2007
C. Ren

We have developed a Lagrangian air-parcel cirrus model (LACM), to diagnose the processes controlling water in the tropical tropopause layer (TTL). LACM applies parameterised microphysics to air parcel trajectories. The parameterisation includes the homogeneous freezing of aerosol droplets, the growth/sublimation of ice particles, and sedimentation of ice particles, so capturing the main dehydra...

2017
Kathrin Heinzmann Davina Jean Honess David Yestin Lewis Donna-Michelle Smith Christopher Cawthorne Heather Keen Sandra Heskamp Sonja Schelhaas Timothy Howard Witney Dmitry Soloviev Kaye Janine Williams Andreas Hans Jacobs Eric Ofori Aboagye John Richard Griffiths Kevin Michael Brindle

Background: Recent studies have shown that 3′-deoxy-3′-[F] fluorothymidine ([F]FLT)) uptake depends on endogenous tumour thymidine concentration. The purpose of this study was to investigate tumour thymidine concentrations and whether they correlated with [F]FLT uptake across a broad spectrum of murine cancer models. A modified liquid chromatography-mass spectrometry (LC-MS/MS) method was used ...

Journal: :The Journal of Cell Biology 2006
Leticia Peris Manuel Thery Julien Fauré Yasmina Saoudi Laurence Lafanechère John K. Chilton Phillip Gordon-Weeks Niels Galjart Michel Bornens Linda Wordeman Juergen Wehland Annie Andrieux Didier Job

Tubulin-tyrosine ligase (TTL), the enzyme that catalyzes the addition of a C-terminal tyrosine residue to alpha-tubulin in the tubulin tyrosination cycle, is involved in tumor progression and has a vital role in neuronal organization. We show that in mammalian fibroblasts, cytoplasmic linker protein (CLIP) 170 and other microtubule plus-end tracking proteins comprising a cytoskeleton-associated...

2007
Qiang Fu Yongxiang Hu Qiong Yang

[1] We identify the top of the tropical tropopause layer (TTL) by analyzing the vertical mass flux profile based on radiative transfer calculations employing observed atmospheric profiles and cloud information. We find that the top of the TTL is located at 18.7 km (70 mb). We have analyzed the CALIPSO lidar cloud observations from June 2006 to February 2007, which indicates that almost no cloud...

2017
Young Chan Kim Tulyapruek Tawonsawatruk Hyeong Hwa Woon Ji Woong Yum Myung Jin Shin Rodolfo S. Bravo Kyung Wook Nha

Purpose The effect of sagittal plane angle of the tibial tunnel on the severity of tibial intra-articular aperture expansion caused by iatrogenic re-reaming in anterior cruciate ligament (ACL) reconstruction using a modified transtibial technique is unknown. The purpose of this study was to compare the severity of intra-articular aperture widening at different angles (40°, 45°, and 50°) of the ...

2002
H. Dhong M. Tanaka S. W. Tomashot

Low-noise lTL-compatible off-chip driver (OCD) circuits are very important, especially for low-power electronics, but scaled-down CMOS technology requires a lower operating voltage of 3.3 V, while most applications require 5 V. The dual power-supply requirement makes the design of OCD challenging, first because pull-up devices, especially p-MOS devices, must be able to handle an off-chip voltag...

2007
Vincenza Carchiolo Michele Malgeri Giuseppe Mangioni

The problem of designing and specifying complex systems for which constraints of time and synchronization with the outside world or other systems-have to be respected is a highly debated topic. It is generally dealt with by imposing precise design methods which make it possible to verify that the results obtained meet the requirements laid down when the system is deened (CAD methods and softwar...

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