Abstract Background Bowel urgency, the sudden and immediate need to have a bowel movement, is common symptom in ulcerative colitis (UC) associated with higher disease activity, decreased work productivity markedly reduced quality of life1. This study explored differences burden among UC patients urgency based on their treatment pathway. Methods Data were extracted from Adelphi Disease Specific ...

The feasibility of selectively eliminating human antigen-specific B cell responses by treating cells in vitro with antigen covalently linked to a cell toxin was examined. Tetanus toxoid (TT) was conjugated to the toxin ricin via a thioether linkage. Peripheral blood mononuclear cells from recently immunized subjects were preincubated for 2 h with TT-ricin in the presence of lactose. Antigen was...

We study possible real structures in the space of solutions to the quantum differential equation. We show that, under mild conditions, a real structure in orbifold quantum cohomology yields a pure and polarized tt-geometry near the large radius limit. We compute an example of P which is pure and polarized over the whole Kähler moduli space H(P,C).

Previously, we demonstrated that administering vitamin A supplements to children resulted in a significant increase in the immunoglobulin G (IgG) response generated against a vaccine dose of tetanus toxoid (TT) (R. D. Semba et al., J. Nutr. 122:101-107, 1991). However, from these analyses we could not determine whether there was an increase in levels of IgG of the subclass presumed to be import...

ABSTRACT We introduce zeus, a well-tested Python implementation of the Ensemble Slice Sampling (ESS) method for Bayesian parameter inference. ESS is novel Markov chain Monte Carlo (MCMC) algorithm specifically designed to tackle computational challenges posed by modern astronomical and cosmological analyses. In particular, requires only minimal hand-tuning 1−2 hyperparameters that are often tri...

ABSTRACT General circulation models (GCMs) provide context for interpreting multiwavelength, multiphase data of the atmospheres tidally locked exoplanets. In current study, non-hydrostatic THOR GCM is coupled with HELIOS radiative transfer solver first time, supported by an equilibrium chemistry (FastChem), opacity calculator (HELIOS-K), and Mie scattering code (LX-MIE). To accurately treat rad...

We present parallel algorithms and data structures for three fundamental operations in Numerical Linear Algebra: (i) Gaussian CountSketch random projections their combination, (ii) computation of the Gram matrix (iii) squared row norms product two matrices, with a special focus on "tall-and-skinny" which arise many applications. provide detailed analysis ubiquitous transform its combination pro...

OBJECTIVES To assess the evidence showing that a specific method of toilet training (TT) is more effective than others, as any method of TT recommended by a physician faces obstacles because parents rarely request advice on TT from physicians, and TT practices vary tremendously across cultures and socioeconomic levels. METHODS Reports on the natural course of urinary incontinence in children ...

INTRODUCTION Treatment with ritonavir-boosted protease inhibitors and nucleoside analogues frequently leads to rises in lipids, which might increase the cardiovascular risk. The aim of this study was to describe changes in lipid levels among HIV positive patients participating in the GARDEL study. MATERIALS AND METHODS The GARDEL study compared the efficacy and safety of a dual therapy (DT) c...