We have investigated the molecular requirements for thrombospondin (TSP) to bind to the platelet surface and to support the subsequent secretion-dependent platelet aggregation. For this, we used two distinct murine monoclonal antibodies (MoAbs), designated MAI and MAII, raised against human platelet TSP, and three polyclonal antibodies, designated R3, R6, and R5, directed against fusion protein...

In this research, a person-delay-based optimization method is proposed for an intelligent Transit Signal Priority (TSP) logic that resolves multiple conflicting TSP requests at an isolated intersection. This TSP with Connected Vehicles accommodating Conflicting Requests (TSPCV-CR) overcomes the challenge bore by the conventional ‘‘first come first serve” strategy and presents significant improv...

  The underlying mechanisms leading to the development of human T-cell lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP) in HTLV-I infected individuals are not fully understood. Host genetic factors appear to be involved as risk factors for developing HAM/TSP. We investigated the possible contribution of interleukin-10 (IL-10) as a risk factor to HA...

We explored the role that thrombospondin (TSP), a multifunctional extracellular matrix protein, plays in hematopoietic cell-cell and cell-matrix interactions. Thrombospondin synthesis is differentially regulated in human long-term bone marrow cultures. Consistent with this, human hematopoietic progenitor cells of all three lineages (erythrocyte, megakaryocyte, and granulocyte) use TSP as an att...

Tamarind (Tamarindus indica L) seed polysaccharide (TSP) is of great important due to its various biological activities. The present investigation was carried out to compare extraction yield, morphological characteristics, average molecular weights and antioxidant activities of TSP from gammaand electron beam (EB)-irradiated tamarind kernel powder. The tamarind kernel powder was irradiated with...

Thrombospondin-1 (TSP) is a transiently expressed matricellular protein known to promote chemotaxis of leukocytes to inflammatory sites. However, TSP and its receptor CD36 are abundantly expressed in chronically inflamed tissues such as the rheumatoid synovium. Here, we show that TSP provides the costimulatory signal that is necessary for the activation of autoreactive T cells. Data presented r...

Thrombospondin 1 (TSP-1) is abundantly expressed in visceral adipose tissue and this expression is up-regulated in obese humans and rodents. Recent studies showed that genetic deletion of TSP-1 protects mice from diet-induced insulin resistance. However, the molecular mechanism is largely unknown. In this study, we examined the effect of recombinant TSP-1 on insulin signaling in cultured cells ...

OBJECTIVE HTLV-1 proviral loads (PVLs) and some genetic factors are reported to be associated with the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). However, there are very few reports on HAM/TSP having family history. We aimed to define the clinical features and laboratory indications associated with HAM/TSP having family history. METHODS Records of 784 ...

Transportation Research Record: Journal of the Transportation Research Board, No. 2311, Transportation Research Board of the National Academies, Washington, D.C., 2012, pp. 186–194. DOI: 10.3141/2311-18 Department of Civil and Environmental Engineering, Portland State University, P.O. Box 751, Portland, OR 97207. Corresponding author: E. Albright, [email protected]. of buses over passenger vehicles (...