Although the collecting duct is regarded as the primary site at which mineralocorticoids regulate renal sodium transport in the kidney, recent evidence points to the distal convoluted tubule as a possible site of mineralocorticoid action. To investigate whether mineralocorticoids regulate the expression of the thiazide-sensitive Na-Cl cotransporter (TSC), the chief apical sodium entry pathway o...

OVERVIEW T uberous sclerosis complex (TSC) is a dominantly inherited, genetic disorder affecting cellular differentiation, proliferation and migration early in development, resulting in the development of tumors in multiple organ systems, often referred to as hamartias and hamartomas. The diagnosis of TSC and evaluation of at-risk persons involves careful examination of the skin, heart, lungs, ...

Commentary The mammalian target of rapamycin (mTOR) is a ubiquitous protein kinase that has received extensive attention in recent years as a potential mediator of epilepsy. mTOR, particularly a specific complex of proteins called mTORC1, regulates numerous cellular and physiologic functions, including protein synthesis , cell growth, proliferation, autophagy, and metabolism. Abnormal regulatio...

Limited information is available about epigenetic mechanisms by which cigarette smoke enhances the initiation and progression of lung cancer. To examine this issue, A549 and Calu-6 lung cancer cells were cultured in normal media with or without tobacco smoke condensate (TSC) under clinically relevant exposure conditions. Ten-day TSC exposure dramatically increased the tumorigenicity of lung can...

IEEE Transactions on Services Computing (TSC) will celebrate its ninth anniversary in 2016. In the first issue of 2016, I would like to report the achievements of TSC to our readers, authors, reviewers, TSC editorial board and TSC executive advisory board. First, TSC has gained its impact factor of 3.049 and its five-year impact factor of 3.181, which places TSC in the elite class of highly ran...

Commentary Tuberous sclerosis complex (TSC) is one of the most common genetic etiologies of epilepsy. Epilepsy in TSC patients may involve multiple seizure types and is often intractable to medication. TSC is caused by mutation of either the TSC1 or TSC2 gene and is characterized pathologically by the development of hamartomas or tumors in multiple organs. Cortical tubers, hamartomatous lesions...