Thymidylate synthase (TS), which catalyzes the de novo synthesis of dUMP, is an important target for cancer therapy. In this report, the effects of 5-fluorouracil (5-FU) and ZD1694 on the regulation of TS gene expression were evaluated in zebrafish embryos. Our results revealed that the expression of TS was increased by about six-fold when embryos were treated with 1.0 microM 5-FU and there was...

Tamoxifen is routinely used for treatment of Estrogen-positive breast carcinoma. Approximately, 50% of patients with metastatic cancer will develop resistance to Tamoxifen. In this research, Tamoxifen was combined with the anti-cancer compound Curcumin. Diblock nanopolymer was used to package the new formulation of Curcumin and Tamoxifen. Anti-cancer efficacy of the obtained compound was evalua...

We study how to derive a fuzzy rule-based classification model using the theoretical framework of belief functions. For this purpose we use the recently proposed Evidential c-means (ECM) to derive Takagi-Sugeno (TS) models solely from data. ECM allocates, for each object, a mass of belief to any subsets of possible clusters, which allows to gain a deeper insight in the data while being robust w...

Thymidylate synthase (TS) is the only de novo source of thymidylate (dTMP) for DNA synthesis and repair. Drugs targeting TS protein are a mainstay in cancer treatment, but off-target effects and toxicity limit their use. Cytosolic thymidine kinase (TK1) and mitochondrial thymidine kinase (TK2) contribute to an alternative dTMP-producing pathway, by salvaging thymidine from the tumor milieu, and...

The catalytic performances over propylene epoxidation with H2 and O2 (HOPO process) are significantly affected by the properties (e.g., surface properties, Ti coordination, morphology) of titanosilicate zeolite. Introducing urea into zeolite synthesis is a simple convenient method to modify these Uncalcined pore-blocked titanium silicalite-1 (TS-1, i.e., TS-1-B) lower dosage possesses more defe...

   In cross docking strategy, arrived products are immediately classified, sorted and organized with respect to their destination. Among all the problems related to this strategy, the vehicle routing problem (VRP) is very important and of special attention in modern technology. This paper addresses the particular type of VRP, called VRPCDTW, considering a time limitation for each customer/retai...

1672 www.thelancet.com Vol 370 November 17, 2007 animal studies should be acknowledged, since some reports have suggested that rimonabant might have antidepressant or anxiolytic actions. Another observation that might provide an alternative physio logical basis for increased mood disorders seen with greatest weight-loss comes from evidence that leptin, the adipose-derived hor mone, had an antid...

islamic medical jurisprudence, which is the subjectconcemed with the application of islamic laws to the area of medicine, has never been discussed as an independent field of jurisprudence, although several selected topics, especially those concerning food and beverages, sexuality, death, wounds and injuries, and doctor-patient relations have been more discussed than others. the results of an in...

Thymidylate synthase (TS) is responsible for the de novo synthesis of thymidylate, which is required for DNA synthesis and repair and which is an important target for fluoropyrimidines such as 5-fluorouracil (5-FU), and antifolates such as Tomudex (TDX), ZD9331, and multitargeted antifolate (MTA). To study the importance of TS expression in determining resistance to these agents, we have develo...