LOCAL REMODELING OF chromatin is a key step in the transcriptional activation of genes. Dynamic changes in the nucleosomal packaging of DNA must occur to allow transcriptional proteins contact with the DNA template. The realization that the proteins that regulate the modification of chromatin are themselves disrupted in many leukemic chromosomal rearrangements has generated new excitement in th...

A bubble cell capillary classically used to extend the optical path length for UV-vis detection is employed here to trap magnetic beads. With this system, a large amount of beads can be captured without inducing a strong pressure drop, as it is the case with magnetic beads trapped in a standard capillary, thereby having less effect on the experimental conditions. Using numerical simulations and...

The cy<:101GOIJ01C identity, that 1 1-az 00 n=l (_1_) M(o:,n) 1 zn ' where M(a,n) = *-:L:dlnJ.L (~) ad, and J. L is the classical Mobius function , has several natural analogues. Polynomials in a of degree n related to M(a, n) in these identities share interesting properties with M(a, n). Many special cases are of combinatorial interest. 1. The Witt formula and a product expansion The function ...

BACKGROUND Each year, millions of platelet transfusions save the lives of cancer patients and patients with bleeding complications. However, between 10 and 30% of all platelet transfusions are clinically ineffective as measured by corrected count increments, but no test is currently used to identify and avoid these transfusions. ThromboLUX(®) is the first platelet test intended to routinely cha...

BACKGROUND Intraperitoneal carcinmatosis and intra-abdominal tumour cell dissemination may occur with several tumour entities. At this final stage of the tumour disease, systemic chemotherapy remains only palliative and may be accompanied by severe side-effects. Alternatively, compartment-based therapy by intraperitoneal (i.p.) instillation of doxorubicin drug-eluting beads (dox-DEB) has been p...

The purpose of this study was to improve the entrapment efficiency of the water-soluble drug metronidazole using internal cross-linking agents. Calcium pectinate beads containing metronidazole were prepared by dropping a drug-pectin solution in 1% and 5% (m/V) calcium chloride for surface cross-linked beads. For the core cross-linked beads calcium carbonate was dispersed in the drug-pectin solu...

A new emulsion gelation method was used to prepare gel beads for a highly water-soluble drug metformin hydrochloride using sodium alginate as the polymer. The gel beads containing oil was prepared by gently mixing or homogenizing oil and water phase containing sodium alginate which was then extruded into calcium chloride solution to produce gel beads. The effects of factors like type of oil and...

In research areas such as decision support systems, one of the crucial features is the ability to automatically explain decisions. However, this ability does not typically play a large role in computer games. Here, I suggest that this situation will change: research on the automatic generation of explanations will have real import for many types of computer games. I discuss four possible ways t...

BACKGROUND The aim of this study was to investigate the deadtime (DT) effects that are present in 177Lu images acquired after radionuclide therapy injection, assess differences in DT based on the full spectrum and the photopeak-only measurements, and design a method to correct for the deadtime losses. A Siemens SymbiaT SPECT/CT camera with a medium energy collimator was used. A 295-mL bottle wa...