Information about the relationship between pharmacological parameters and an early virological response to tipranavir (TPV) is scarce. Human immunodeficiency virus (HIV)-infected patients who had received TPV as part of a salvage regimen were analyzed retrospectively. A virological response was defined as a decline in the HIV RNA level of > or = 1 log unit or to <50 copies/ml between weeks 4 an...

OBJECTIVE To investigate the relationship between platelet count and serum valproic acid level, age, duration of valproic acid therapy, and polytherapy, and to determine the clinical significance of thrombocytopenia associated with high-dosage valproic acid therapy. DESIGN Cross-sectional study. SETTING Residential unit for neurologically impaired children and paediatric out-patient clinic,...

During September–October 2001, the East Pacific Investigation of Climate Processes in the Coupled Ocean– Atmosphere System (EPIC-2001) intertropical convergence zone (ITCZ) field campaign focused on studies of deep convection in the warm-pool region of the eastern Pacific. This study combines C-band Doppler radar, sounding, and surface heat flux data collected aboard the R/V Ronald H. Brown dur...

Morning blood pressure (BP) surge is reported as a risk factor for cardiovascular events and end-organ damage independent of the 24-h BP level. Controlling morning BP surge is therefore important to help prevent onset of cardiovascular disease. We compared the efficacy of azilsartan and candesartan in controlling morning systolic BP (SBP) surges by analyzing relevant ambulatory BP monitoring da...

The vancomycin dose necessary for the achievement of target serum trough concentrations during continuous venovenous hemofiltration (CVVH) remains to be elucidated. This was a retrospective cohort study of critically ill adults at a tertiary medical center on concurrent CVVH and vancomycin between 2006 and 2010 with a steady-state vancomycin trough concentration. The 87 included patients were g...

OBJECTIVE To compare the pharmacokinetic profile of gentamicin given as a once daily dose as against the conventional twelve hourly dose in preterm neonates. DESIGN Randomized double blind study. SETTING Tertiary level Neonatal Intensive Care Unit. SUBJECTS Eighteen preterms admitted during the period January 1994 to May 1994. METHODS The babies were randomly assigned to receive either ...