Placental site trophoblastic tumor (PSTT) is a highly rare form of gestational trophoblastic diseases that arise from intermediate trophoblastic cells. By presenting this case, we aimed to review the treatment and diagnosis, approach to PSTT. A 31-year-old (G2P1A1L1) patient had abnormal vaginal bleeding. Serum ß-HCG was 5.82 mIU/ml and the transvaginal USG detected a polypoid mass in uterine c...

Gestational trophoblastic disease (GTD) is a spectrum of cellular proliferations arising from the placental villous trophoblasts encompassing four main clinicopathologic forms : hydatidiform mole (complete and partial), invasive mole, choriocarcinoma and placental site trophoblastic tumor (PSTT). Placental site trophoblasic tumours (PSTT) are rare and usually diagnosed after dilatation and cure...

Epithelioid trophoblastic tumor is an unusual type of trophoblastic tumor. Here we report on the clinicopathologic and immunohistochemical features of three cases of epithelioid trophoblastic tumor. All three patients were of reproductive age and presented with vaginal bleeding and mild elevation of human chorionic gonadotropin (hCG). All patients underwent a hysterectomy. The tumors consisted ...

PURPOSE Increasing new blood vessel formation (neoangiogenesis) within tumors is an adverse prognostic factor for survival in several cancers. Neoangiogenesis is usually determined histopathologically and not in vivo. To assess neoangiogenesis in vivo, we have used Doppler ultrasonography (US) to measure the uterine artery pulsatility index (UAPI) in patients with gestational trophoblastic tumo...

Placental polyp is retained placental tissue within the endometrial cavity, which forms a nidus for inflammation and bleeding. rare entity with an incidence of less than 0.25% all pregnancies as reported. Here, we report case 23-year-old P2L2 woman complaints intermittent vaginal bleeding since her recent normal delivery, 1.5 months back. A polypoid mass (51×41 mm) abundant vascularity was dete...

Trophoblastic diseases are mainly hydatidiform mole and choriocarcinoma, where the latter is usually the sequela of molar pregnancy and malignant systemic disease with general metastases destructing various tissues and organs till she die. High level urinary hCG, real-time B-mode and color Doppler imaging detect hydatidiform mole in early gestation, postmolar persistent trophoblastic disease is...

Gestational trophoblastic disease (GTD) is a group of conditions that originate from the abnormal hyperproliferation of trophoblastic cells, which derive from the trophectoderm, the outer layer of the blastocyst that would normally develop into the placenta during pregnancy. GTDs encompass hydatidiform mole (HM) (complete and partial), invasive mole, gestational choriocarcinoma, placental-site ...

Modern chemotherapy combined with surgery can achieve complete cure in over 90% of all patients with malignant testicular germ cell tumors. Even tumors that have already metastasized at the time of orchidectomy are curable by platinum-based multidrug treatment. Chemotherapy related changes can be seen in the residual tumor tissue in metastatic sites. In patients fully responding to chemotherapy...

Although 5-fluorouracil (5-Fu) combination chemotherapy provides a satisfactory therapeutic response in patients with gestational trophoblastic neoplasms (GTNs), it has severe side effects. The current study analyzed the therapeutic effects and side effects of tegafur plus actinomycin D (Act-D) vs. 5-Fu plus Act-D for the treatment of GTNs based on controlled historical records. A total of 427 ...

2015 Vol 7 No 1 South Afr J Gynaecol Oncol Elhassan MMA,1 FCRadOnc, MMedRadOnc, Radiation Oncologist Wu H-T,2 FCPathAnat, MMed, Senior Consultant Van Wijk AL,3 FFRAD(T), Senior Consultant Radiation Oncology Department, National Cancer Institute, University of Gezira, Wad Madani, Sudan Department of Anatomical Pathology, University of Cape Town, Cape Town National Health Laboratory Service, Groo...