Muscarinic M(2) receptors preferentially couple with the G(i/o) class of G-proteins to inhibit cAMP synthesis. However, they can also stimulate net synthesis of cAMP and inositol phosphate (IP) accumulation. We investigated in intact Chinese hamster ovary (CHO) cells expressing human M(2) receptors (CHO-M(2) cells) whether direct interaction of M(2) receptors with G(s) and G(q/11) G-proteins is...

Metabolomics, a modern branch of chemical biology, provides qualitative and quantitative information about the metabolic states of organisms or cells at the molecular level. Here we report non-targeted, metabolomic analyses of human blood, using liquid chromatography-mass spectrometry (LC-MS). We compared the blood metabolome to the previously reported metabolome of the fission yeast, Schizosac...

1. Three tetracarboxylate porphyrins, apart from coproporphyrin, were isolated from the faeces of patients with symptomatic cutaneous hepatic porphyria and of rats with porphyria caused by hexachlorobenzene poisoning. The porphyrins were not present in the urine of the porphyric rats or in the faeces of control rats. 2. Two of the porphyrins were identified as tris-(2-carboxyethyl)-carboxymethy...

Inhibition of α-amylase and α-glucosidase, advanced glycation end products (AGEs) formation, and oxidative stress by isolated active constituents of Osmanthus fragrans flowers (9,12-octadecadienoic acid and 4-(2,6,6-trimethyl-1-cyclohexenyl)-3-buten-2-one) and their structural analogues were evaluated. 9,12-Octadecadienoic acid was 10.02 and 22.21 times more active against α-amylase and α-gluco...

Abstract With the rapid development of wearable devices, there is an increasing demand for ultra-safe flexible lithium-ion batteries (LIBs) capable delivering high energy density. Because it can provide highest possible capacity 3860 mAh g-1, lithium metal has drawn tremendous research attention. However, Li a highly reactive that grows dendrites during cycling lithium-metal (LMBs). To resolve ...

Phosphorothioate has proven to be a useful skeleton in organic synthesis as a valuable building block, in pharmaceuticals and pesticides due to its biological and physical properties. In particular, S-aryl phosphorothioate represents an important structural element in antiproliferative agents (A), pesticides (B), antibacterials (C), curing accelerators (D), antistatic agents (E), and anticholin...

phosphorus solubilizing microorganisms are capable of transforming insoluble phosphorus (p) forms to soluble and bioavailable p. the aim of the present study was to isolate p solubilizing bacteria from forest soils around the rock phosphate (rp) mine of koh-e-sepidlar in kohgiluyeh and boyer ahmad province and evaluate their ability in sperber culture medium and wheat straw medium in the presen...

The mol-ecule of the title compound, C(9)H(12)O(2), is approximately planar (mean atomic deviation = 0.0346 Å) and disposed about a crystallographic centre of symmetry. The H atom of the benzene ring is disordered over four orientations, with occupancies of 0.100 (3) and 0.401 (3) at the C atoms in the 2- and 3-positions and the same at their symmetric location. The H atoms of methyl group at t...

some oxime ether derivatives of α-ionone (4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one) have been synthesized. reaction of 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-ketoxime with various chloro and fluoro aromatic and hetero aromatic compounds gave the corresponding oxime ether derivatives via aromatic nucleophilic substitution (snar). the structures of these compounds were elucida...