<b><i>Introduction:</i></b> The presence of mercury in the environment is a worldwide concern. Inorganic present industrial materials, employed medical devices, widely used batteries, component fluorescent light bulbs, and it has been associated with human poisoning gold mining areas. nephrotoxicity induced by inorganic relevant health problem mainly developing countries...

Trimetazidine (TMZ), an anti-ischemic metabolic drug, is used to treat chest pain (angina pectoris). We hypothesized that derivatives of TMZ with antioxidant functions may improve the cardiac dysfunction caused by ischemia-reperfusion (I/R) above that observed with TMZ alone. Isolated rat hearts perfused with Krebs-Henseleit buffer according to the Langendorff method were subjected to 30 min of...

BACKGROUND Organic inflammatory response is a pathophysiological mechanism present at every coronary artery bypass grafting with extracorporeal circulation (CABG-ECC), the release of inflammatory mediators being one of its defense mechanisms. OBJECTIVE To assess, in a prospective double-blind randomized and placebo-controlled study, the effects of trimetazidine (Tmz) on the inflammatory respo...

BACKGROUND The ischemia and reperfusion ischemia is a common physiopathological mechanisms, which has difficult control during Coronary Artery Bypass Grafting (CABG) with cardiopulmonary bypass, the critical moment of which happening by the end of surgery, when there is declamping of aorta and release of hyperoxic radicals causing the injury. OBJECTIVE Evaluate, in a randomized double-blind p...

During the past decade significant declines in cardiovascular mortality have been observed due to the wider use of reperfusion and the optimization of medical therapy. Although rates of procedural success are high in patients with acute and chronic ischemic heart disease, improvement in heart function is not always achieved due to reperfusion injury, microvascular obstruction and the no-reflow ...

BACKGROUND Mesenchymal stem cell (MSC) transplantation is a promising therapy for cardiac repair. However, the efficacy is limited by the poor viability of MSCs in the infarcted heart. Recent findings have implicated that trimetazidine (TMZ) enhanced the survival of the stem cells under various conditions. However, as the stem cells in these studies were animal-derived, little information is av...