Living cells are realized by complex gene expression programs that are moderated by regulatory proteins called transcription factors (TFs). The TFs control the differential expression of target genes in the context of transcriptional regulatory networks (TRNs), either individually or in groups. Deciphering the mechanisms of how the TFs control the differential expression of a target gene in a T...

Primate tripartite motif 5alpha (TRIM5alpha) proteins mediate innate intracellular resistance to retroviruses. In humans, TRIM5 is located in a paralogous cluster that includes TRIM6, TRIM34, and TRIM22. Although TRIM6 and TRIM34 orthologs are found in other mammals, TRIM5 has to date been identified only in primates. Cow cells exhibit early blocks to infection by several retroviruses. We ident...

Estimating the line origin of chromosomal sections from marker genotypes is a vital step in quantitative trait loci analyses of outbred line crosses. The original, and most commonly used, algorithm can only handle moderate numbers of partially informative markers. The advent of high-density genotyping with SNP chips motivates a new method because the generic sets of markers on SNP chips typical...

It is known that the existence of publication bias can influence the conclusions of a meta-analysis. Some methods have been developed to deal with publication bias, but issues remain. One particular method called 'trim and fill' is designed to adjust for publication bias. The method, which is intuitively appealing and comprehensible by non-statisticians, is based on a simple and popular graphic...

This paper presents a static aeroelastic model and longitudinal trim model for the analysis of a flexible wing transport aircraft. The static aeroelastic model is built using a structural model based on finite-element modeling and coupled to an aerodynamic model that uses vortex-lattice solution. An automatic geometry generation tool is used to close the loop between the structural and aerodyna...

This study uses simulated meta-analysis to assess the effects of publication bias on meta-analysis estimates and to evaluate the efficacy of the trim and fill method in adjusting for these biases. The estimated effect sizes and the standard error were evaluated in terms of the statistical bias and the coverage probability. The results demonstrate that if publication bias is not adjusted it coul...

The new Lcica RM 2165 automatic, heavy-duty microtome has an advanced step motor that permits an exact specimen feed and reproducible sectioning results. Features include 70 mm vertical stroke length, unique step trim function, and programmable specimen retraction. Technical features include a handwheel rocking sectioning mode; the motorized specimen feed can be linked to change the handwheel t...

This paper presents a performance model of the ATA/ATAPI SSD Trim command under various types of user workloads, including a uniform random workload, a workload with hot and cold data, and a workload withN temperatures of data. We first examine the Trim-modified uniform random workload to predict utilization, then use this result to compute the resultant level of effective overprovisioning. Thi...

In this paper, a vocabulary trim down algorithm is proposed in decision tree-based acoustic model to make the model more close to the given task. Using this trim down model as seed model to do task adaptation is also presented. Based on this framework, users can configure the acoustic model by themselves according to their resources (such as vocabulary knowledge, a little amount task specific d...

TRIM-NHL proteins are highly conserved regulators of developmental pathways in vertebrates and invertebrates. The TRIM-NHL family member NHL-2 in Caenorhabditis elegans functions as a miRNA cofactor to regulate developmental timing. Similar regulatory roles have been reported in other model systems, with the mammalian ortholog in mice, TRIM32, contributing to muscle and neuronal cell proliferat...