A sensitive, isocratic reversed-phase high performance liquid chromatographic method involving fluorescence detection was developed for the determination of donepezil hydrochloride in tablets and in human plasma. Pindolol was used as an internal standard. Good chromatographic separation was achieved by using an analytical column C18. The system operated at room temperature using a mobile phase ...

O tromboembolismo pulmonar (TEP) é uma entidade relativamente frequente no contexto de urgência hospitalar, com uma elevada taxa de mortalidade e morbilidade quando não tratado precocemente, continuando a representar um desafio diagnóstico na prática clínica diária, sendo a sua apresentação clínica nem sempre esclarecedora, especialmente no contexto agudo1. A mortalidade de doentes por TEP nos ...

OBJECTIVES To investigate whether mean platelet volumes and leukocyte counts are altered significantly in patients with tubal ectopic pregnancy (TEP). MATERIALS AND METHODS Retrospective analysis of mean platelet volumes and leukocyte counts of 138 TEP patients, diagnosed between 2005 and 2012, and the control group consisting of 72 pregnants was performed. Patients with TEP were further subd...

This study explores the role of transparent exopolymer particles (TEP) as an additional carbon source for heterotrophic microbial activity in the eutrophic Qishon estuary. From the coastal station and upstream the estuary; TEP concentrations, β-glucosidase activity, bacterial production and abundance have gradually increased. TEP were often found as bio-aggregates, scaffolding algae, detritus m...

A stability indicating reversed phase HPLC assay method has been used for the simultaneous assay of piracetam and cinnarizine drugs in hard gelatin capsule formulation. The separation is achieved by gradient elution using Hypersil BDS C8 column (250 mm × 4.6 mm, i.d. 5 μm particle size) with mobile phase (A) consisting of 0.015 M dipottassium hydrogen phosphate and 2 mL of triethyl amine adjust...

Cellulose is the most abundant biopolymer in nature and has a broad range of applications in the pharmaceutical, food and biomedical fields. This review article describes the functionalization conditions, crosslinking agents, reaction pathways and the resulting physicochemical and mechanical properties of functionalized cellulose derivatives. The discussion is focused on aqueous reactions and c...

The present study was conducted to prepare sustained release microspheres of naproxen sodium using ethyl cellulose (Ethocel 20 cps) polymer. Three different plasticizers namely polyethyleneglycol 600 (PEG 600), polyethyleneglycol 6000 (PEG 6000) and triethyl citrate (TEC) were used at 10% (wt/wt) and 40% (wt/wt) level of the drug content. Prepared microspheres were characterized with respect to...

BACKGROUND Lichtenstein's technique is considered the reference technique for inguinal hernia repair. Recent trials suggest that the totally extraperitoneal (TEP) technique may lead to reduced proportions of chronic pain. A systematic review evaluating the benefits and harms of the TEP compared with Lichtenstein's technique is needed. METHODOLOGY/PRINCIPAL FINDINGS The review was performed ac...

Developing advanced electrolytes is critical for stabilizing electrode/electrolyte interfacial reactions and thus extending cycling stability of sodium (Na) batteries, especially when a high-voltage cathode (such as NaNi0.68Mn0.22Co0.10O2 (NaNMC)) used to achieve high energy density in batteries. Here, an electrolyte based on bis(fluorosulfonyl)imide (NaFSI)–triethyl phosphate, which highly sta...