An improved multistep synthesis of tricyclic α-cyanopyrrolidine from camphor is presented. The synthesis was carried out by maintaining the cyano group in the form of an amide and its regeneration after the completion of the necessary chemical transformation of a particular functional group. The tricyclic α-cyanopyrrolidine prepared was used to synthesize two novel compounds of DPP4 (Dipeptidyl...

A 22 year old woman was admitted with amitriptyline overdose. Twenty six hours later she developed acute myocardial infarction. Cardiotoxic effects of tricyclic antidepressants are discussed and the importance of considering myocardial infarction as a complication of tricyclic antidepressant overdose is emphasized.

Tricyclic antidepressants (TCAs) may have dangerous cardiac effects in overdose. ECG is useful as both a screening tool for tricyclic antidepressant exposure and as a prognostic indicator. TCA overdose may produce various ECG changes. We report a case of Dothiepin overdose resulting in Brugada like pattern including RBBB which resolved spontaneously.

let $n$ be any positive integer, the friendship graph $f_n$ consists of $n$ edge-disjoint triangles that all of them meeting in one vertex. a graph $g$ is called cospectral with a graph $h$ if their adjacency matrices have the same eigenvalues. recently in href{http://arxiv.org/pdf/1310.6529v1.pdf}{http://arxiv.org/pdf/1310.6529v1.pdf} it is proved that if $g$ is any graph cospectral with $f_n$...

Many existing degree based topological indices can be clasified as bond incident degree (BID) indices, whose general form is BID(G) = ∑ uv∈E(G) Ψ(du, dv), where uv is the edge connecting the vertices u, v of the graph G, E(G) is the edge set of G, du is the degree of the vertex u and Ψ is a non-negative real valued (symmetric) function of du and dv. Here, it has been proven that if the extensio...

This review, together with Part 1 (Gun. Chem. 26: 5-17, 1980), summarizes progress in measurement of tricyclic antidepressants in biological fluids and the application of the methodology to Clinical practice. For many of the older drugs and for all of the new-generation antidepressants, further studies are required to delineate the precise relationship between plasma concentration and clinical ...