Pyridine containing water clusters, H(+)(pyridine)(m)(H(2)O)(n), have been studied both experimentally by a quadrupole time-of-flight mass spectrometer and by quantum chemical calculations. In the experiments, H(+)(pyridine)(m)(H(2)O)(n) with m = 1-4 and n = 0-80 are observed. For the cluster distributions observed, there are no magic numbers, neither in the abundance spectra, nor in the evapor...

Dacarbazine is an antitumor prodrug which is used for the treatment of malignant metastatic melanoma and Hodgkin’s disease. It requires initial activation in liver through an N-demethylationreaction. The active metabolite prevents the progress of disease via alkylation of guanine bases in DNA strands. In order to investigate the importance of imidazole ring and its dynamictautomerization in ant...

The phenyltetrel pyridine-2-olates PhE(pyO)3 (E = Si, Ge, Sn; pyO pyridine-2-olate) were synthesized from the respective chlorides PhECl3 and 2-hydroxypyridine (2-pyridone) with aid of a sacrificial base (triethylamine). Their solid-state structures determined by single-crystal X-ray diffraction. PhSi(pyO)3 exhibits three-fold capped tetrahedral Si coordination sphere ([4+3]-coordination, Si···...

Two A2B cobalt triaryl corroles bearing ester (1) or carboxylic acid group (2) at the 10-para-phenyl were prepared and used as homogeneous electrocatalysts for hydrogen evolution reaction (HER) with acetic water proton sources. CV results revealed HER underwent two routes [CoIII–H]– (EECC pathway) [CoII–H]2– (ECEC intermediates low concentration. While mainly went through ECEC route high The tu...

We have isolated the stable as well as the metastable tautomers of 1-deazapurine in the solid state by exploiting principles of supramolecular selectivity in the context of cocrystal design.

hantzsch 1, 4-dihydropyridines (1,4-dhps) can be oxidized to the corresponding pyridine derivatives by thallium triacetate in high yields.

reaction of tryptamine 1 with dimethyl -3-methoxyallylidenemalonate 2 afforded n?-[4,4-bis (methoxycarbonyl)-1,3-butadienyl] tryptamine 3 which in combination with acetylchloride and pyridine in dichloromethane gave n?, n?-[acetyl]-[(4,4-dinethoxycarbonyl) 1,3butadienyl] tryptamine 4. treatment of 3 with sodium hydroxide afforded 2h[n-(3-indolyl) ethyl] 2-oxo-3-methoxycarbonyl-1-pyridine 5. cyc...

The reactions of isatins, 3-amino-1-pheyl-1H-pyrazol-5(4H)-one, and monocyclic ketones, have been developed for preparation spiro[indoline-3,4'-pyrazolo[3,4-b]quinoline]-2,3'(6'H)-dione, spiro[cyclohepta[b]pyrazolo[4,3-e]pyridine-4,3'-indoline]-2′,3-dione, spiro[cycloocta[b]pyrazolo[4,3-e]pyridine-4,3'-indoline]-2′,3(6H)-dione, spiro[cyclo dodeca[b]pyrazolo[4,3-e]pyridine-4,3'-indoline]-2′,3(6H...

In the last few years, imidazo[1,5-a]pyridine scaffolds and derivatives have attracted growing attention due to their unique chemical structure optical behaviors. this work, a series of pyridylimidazo[1,5-a]pyridine corresponding pyridinium salts were synthesized properties investigated evaluate effect quaternization on features both in solution polymeric matrix. A critical analysis based spect...

Recent advances in pyridine synthesis are described. Modification of traditional condensation strategies continues to be a recurrent theme in contemporary literature. Advancements in transition-metal-catalyzed cyclization and cross-coupling procedures offer new routes to functionalized pyridine derivatives. These recently developed methodologies are a valuable addition to azaheterocycle synthesis.