We investigated the effects of hyperbaric oxygen treatment on the Nrf2 signaling pathway in secondary injury following traumatic brain injury, using a rat model. An improved Feeney freefall method was used to establish the rat traumatic brain injury model. Sixty rats were randomly divided into three groups: a sham surgery group, a traumatic brain injury group, and a group receiving hyperbaric o...

PURPOSE OF REVIEW The aim of this article is to review the current status of protective effects of mild-to-moderate hypothermia on traumatic brain injury. RECENT FINDINGS More than 30 clinical studies have reported effects of therapeutic hypothermia on outcome of traumatic brain injury and cerebral ischemia. Only one clinical trial of short-term mild hypothermia did not show any effect in pat...

Traumatic Brain Injury (TBI) or also known as a head injury is one of the leading causes death among young people and health problems defined impact, penetration, rapid movement brain within skull that can result in changes mental status often referred to silent epidemic. Head injuries electrophysiological abnormalities seen on electroencephalography (EEG) recordings. Electroencephalography was...

STUDY OBJECTIVE We aimed to determine the association between scalp hematoma characteristics and traumatic brain injuries in young children with blunt head trauma who have no other symptoms or signs suggestive of traumatic brain injuries (defined as "isolated scalp hematomas"). METHODS This was a secondary analysis of children younger than 24 months with minor blunt head trauma from a prospec...

OBJECTIVES The goals were to describe trends in pediatric traumatic brain injury hospitalizations in the United States and to provide national benchmarks for state and regional comparisons. METHODS Analysis of existing data (1991-2005) from the Nationwide Inpatient Sample, the largest longitudinal, all-payer, inpatient care database in the United States, was performed. Children 0 to 19 years ...

OBJECTIVE To compare the contents of participation outcome measures in traumatic brain injury with the International Classification of Functioning, Disability and Health (ICF) Core Sets for traumatic brain injury. METHOD A systematic search with an independent review process selected relevant articles to identify outcome measures in participation in traumatic brain injury. Instruments used in...

OF DISSERTATION POST-TRAUMATIC SLEEP FOLLOWING DIFFUSE TRAUMATIC BRAIN INJURY By Rachel Kathleen Rowe Traumatic brain injury (TBI) is a major cause of death and disability throughout the world with few pharmacological treatments available for individuals who suffer from neurological morbidities associated with TBI. Cellular and molecular pathological processes initiated at the time of injury de...

Traumatic brain injury is considered as one of the main causes of morbidity and mortality worldwide. Apart from primary mechanical injury, Secondary injuries due to inflammation and apoptosis result in great neuronal damage. Current treatments are not able to regenerate the damaged part and prevent future sequels. Using human stem cells with self-assembling scaffolds may be promising in treatme...

Introduction: Brain injury is an important cause of morbidity and mortality worldwide and so far, there has been no absolute treatment for the damaged brain tissue. Using human stem cells with self-assembling scaffolds can be a promising method for treatment of traumatic brain injury. Materials and Methods: Human meningioma stem cells were isolated, cultured and then expanded into in vitro cond...

objective: to determine the effects of recombinant human erythropoietin (rhepo) on functional outcome and disability of patients with traumatic cervical spinal cord injury (sci).  methods: this was a randomized, double blind, placebo controlled clinical trial being performed in nemazee and shahid rajaei hospitals of shiraz during a 3-year period from 2011 to 2014. a total number of 20 patients ...